Electricity: measuring and testing – Particle precession resonance – Using a nuclear resonance spectrometer system
Reexamination Certificate
2003-01-22
2004-12-28
Fulton, Christopher W. (Department: 2859)
Electricity: measuring and testing
Particle precession resonance
Using a nuclear resonance spectrometer system
C324S309000
Reexamination Certificate
active
06836113
ABSTRACT:
BACKGROUND OF THE INVENTION
The invention relates to magnetic resonance imaging (MRI), and in particular to high speed echo-planer imaging (EPI) techniques.
EPI is a commonly used MRI technique for high speed acquisition of NMR data, in which scan times are generally about 100 msec. For the simplicity of discussion, the Z-axis is used as the slice selection direction, the X-axis is used as the phase-encoding direction, and the Y-axis is used as the readout direction. However, other orientations may be applied when using the invention described herein.
As shown in
FIGS. 1 and 2
, in a conventional EPI pulse sequence, a 90° radio frequency (RF) excitation pulse
10
with a slice selective magnetic field gradient (G
slice
)
12
is applied along an axis perpendicular to the imaging plane, e.g., (G
z
), to excite the nuclei in the imaging plane of the body being imaged. A phase encoding gradient (G
phase
)
14
and
24
is applied, along an axis (G
x
) parallel to the imaging plane, after the excitation pulse to spatially encode the nuclei. Similarly, a phase shift gradient (G
read
)
16
is applied, along an axis (G
y
) parallel to the imaging plane and orthogonal to the phase encoding gradient, to center the subsequent scanning of the k-space (raw data space). A 180° RF rephasing pulse
18
is applied to generate a spin echo (SE) response (ADC)
20
from the excited nuclei. A slice specific gradient
19
may also be applied in conjunction with the 180° RF pulse.
During a signal sampling period, an alternating readout magnetic field gradient (G
read
)
22
is applied to scan k-space and acquire SE signal samples
20
from the excited nuclei. In combination with the readout gradient, a continuous phase encoding gradient (G
phase
)
24
may be applied to cause the scanning to move along the phase encoding (G
x
) direction, as is shown in FIG.
3
. The scan trajectory
26
forms a zig-zag pattern through k-space due to the alternating readout gradient
22
and the continuous phase encoding gradient
24
. Alternatively, the phase encoding gradient may be applied as blip pulses
28
aligned with the reversal of the readout gradient to shift the scan trajectory
30
after each pass through a row of k-space, as is shown in FIG.
4
.
As is shown in
FIGS. 3 and 4
, data is generally sampled during an EPI sequence in a raster scan trajectory through k-space, where individual scan lines corresponding to the readout gradient are sequentially sampled. After each scan line
32
is sampled, the k-space trajectory is shifted along the phase gradient direction to a next scan line
34
. The reversal of the readout gradient
22
causes the k-space trajectory to be reverse along the readout gradient. By reversing the trajectory, the scan through k-space can proceed back and forth along the readout gradient on a line by line sequence.
The phase encoding gradient
24
,
28
is perpendicular to the line by line trajectory of the data acquisition trajectory. Data along a line parallel to the phase encoding gradient is acquired slowly during the course of an entire scan of k-space. In contrast, data acquired along each line parallel to the readout gradient is acquired quickly as the scanning trajectory passes through one line of the scanning trajectory. Accordingly, data in the phase encoding gradient direction is acquired at a much slower rate than is data collected along the readout gradient direction.
The NMR signal samples acquired during the readout gradient may be transformed from the k-space domain to a spatial domain using conventional mathematical techniques, such as a Fourier transform. Data in the spatial domain is used to generate a NMR image of a cross-section of the body corresponding to the slice selected for imaging.
Images generated using an EPI sequence are susceptible to distortion and artifacts caused by magnetic field inhomogeneities and other abnormalities of the MRI system. With respect to high speed images generated using EPI sequences, the image distortions are particularly acute along the phase encoding direction because of the relatively slow data sampling rate along that direction.
Induced magnetic field distortions are a source of image distortions. An induced field distortion arises when a magnetic field is induced by a switched gradient magnetic field in an MR imaging sequence, an EPI sequence. The induced field is a cross-field when it is orthogonal to the inducing gradient field. Induced magnetic cross-field distortions may result from eddy-currents (EC) and Maxwell electromagnetic fields in the MRI system. For example, during an EPI sequence, an induced cross-field may arise along the phase-encoding direction due to the rapidly switched readout gradient during the data sampling period.
In view of the relatively slow sampling rate along the phase-encoding direction (G
phase
), the gradient induced cross-field due to a switched readout gradient (G
read
) may result in substantial image distortions along the phase-encoding direction. The image distortion may be particularly acute in images generated from an EPI sequence where the readout gradient is repeatedly reversed during the data sampling period. There is a long-felt need for techniques to compensate for induced magnetic cross-fields that create image distortions, especially for distortions resulting from EPI sequences during which induced cross-fields are generated by the readout gradient.
BRIEF SUMMARY OF THE INVENTION
A technique has been developed for compensating for the distortions in the image data due to induced magnetic cross fields, and especially those generated by a switched readout gradient. The compensation technique allows for distortions in images due to induced cross-fields to be substantially reduced. The induced cross-field distortions are often acute along a direction corresponding to the phase-encoding gradient. The compensation technique is most helpful in reducing image distortion along the phase-encode direction.
The compensation technique includes initially measuring the induced magnetic cross-field, preferably by imaging a phantom object. The measurements of the induced cross-field effects in a phantom object are used to generate a cross-term correction factor. This factor is used to reduce image distortion and artifacts due to the cross-field induced during signal sampling of a patient's body.
In one embodiment, the invention is a method for determining a gradient-induced cross-term magnetic field in a magnetic resonance imaging (MRI) system involving the steps of: positioning an object in a static magnetic field; applying a radio frequency (RF) excitation pulse that spatially selects the nuclei of a slice plane in the object; applying an incremental phase-encoding magnetic gradient field along a phase encoding direction perpendicular to the slice direction; applying an RF refocusing pulse that is spatially selective along a readout magnetic gradient field direction, so as to select nuclei of the object along a selected line in said slice plane; sampling nuclear magnetic resonance (NMR) from the selected nuclei by applying a readout magnetic field gradient to the object, wherein the readout gradient repeatedly cycles during a sampling period, generating data corresponding to a phase-encoding gradient k-space value at a series of time points inside the readout duration, and determining a center frequency distribution (CF) along the selected line, where the CF distribution is indicative of a gradient-induced cross-term magnetic field.
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“NMR Imaging For Magnets With Large Nonuniformi
Courson Tania
Fulton Christopher W.
Nixon & Vanderhye P.C.
Toshiba America MRI Inc.
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