Means of preparation and applications of liposomes containing hi

Details Means of preparation and applications of liposomes containing hi Means of preparation and applications of liposomes containing hi

1980-02-20

1982-01-12

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

252316, 252319, 424 9, 424 35, A61K 4900, A61K 4300, B01J 1300

Patent

active

043105068

ABSTRACT:
Unilamellar vesicles comprising a lipid bilayer, an ionophore being incorporated in said lipid bilayer, a chelating agent entrapped within the vesicles, and an effective amount of physiologically compatible cation bound to said chelating agent within the vesicles. Unilamellar vesicles are loaded by incubating the vesicles with the cation, terminating the incubation and recovering the loaded vesicles by chromatography. In some applications of the invention, the cation may be a radioactive tracer, in which case the vesicles can be administered to the human host and observed by scintillation techniques to produce a radioimage which is useful for diagnostic purposes.

REFERENCES:
patent: 3522346 (1970-07-01), Chang
patent: 3663685 (1972-05-01), Evans
patent: 3663686 (1972-05-01), Grotenhuis et al.
patent: 3663687 (1972-05-01), Evans
patent: 3683066 (1972-08-01), Ascanio et al.
patent: 3932657 (1976-01-01), Rahman
patent: 3937668 (1976-02-01), Zolle
patent: 4086330 (1978-04-01), Petkau et al.
patent: 4089801 (1978-05-01), Schneider
patent: 4115536 (1978-09-01), Rothman et al.
patent: 4193983 (1980-03-01), Ullman et al.
Gregoriadis, New Eng. J. Med., vol. 295, Sep. 23, 1976, pp. 704-710.

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