Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-07-12
1999-11-23
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514182, 530399, 540 2, 540114, 540117, A61K 3818, A61K 3156, C07K 14475
Patent
active
059900784
ABSTRACT:
This invention provides a method of increasing the level of estrogen receptors in the neural tissue of a subject which comprises administering to the subject estrogen in an amount effective to increase the level of neurotrophin receptors and a neurotrophin in an amount effective to increase the level of estrogen receptors, so as to thereby increase the level of estrogen receptors. This invention also provides a method of increasing the level of estrogen receptors in a sample of neural tissue from a subject which comprises contacting the sample with estrogen in an amount effective to increase the level of neurotrophin receptors and neurotrophin in an amount effective to increase the level of estrogen receptors, so as to thereby increase the level of estrogen receptors. Lastly, this invention provides a method of preventing the onset of Alzheimer's disease.
REFERENCES:
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Miranda et al, PNAS, vol. 90, Jul. 1993, pp. 6439-6443.
McMillan, P.J., et al. (1996) The Effects of Ovariectomy and Estrogen Replacement on trkA and Choline Acetyltransferase mRNA Expression in the Basal Forebrain of the Adult Female Sprague-Dawley Rat. J. Neurosci. 16(5):1860-1865. (Exhibit B).
Miranda, R.C., et al. (1994) Interactions of Estrogen with the Neurotrophins and Their Receptors During Neural Development Hormones and Behavior 28:367-375. (Exhibit C).
Miranda, R.C., et al. (1993) Neuronal Colocalization of mRNAs for Neurotrophins and Their Receptors in the Developing Central Nervous System Suggests a Potential for Autocrine Interactions Proc. Natl. Acad. Sci. USA 90:6439-6443. (Exhibit D).
Miranda, R.C., et al. (1993) Presumptive Estrogen Target Neurons Express mRNAs for both the Neurotrophins and Neurotrophin Receptors: A Basis for Potential Developmental Interactions of Estrogen with the Neurotrophins Molecular and Cellular Neurosciences 4(6):510-525 (Exhibit E).
Miranda, R.C., and Toran-Allerand, C.D. (1992) Developmental Expression of Estrogen Receptor mRNA in the Rat Cerebral Cortex: A Nonisotopic in situ Hybridization Histochemistry Study Cerebral Cortex 2:1-15. (Exhibit F).
Singh, M., et al. (1995) The Effect of Ovariectomy and Estradiol Replacement on Brain-Derived Neurotrophic Factor Messenger Ribonucleic Acid Expression in Cortical and Hippocampal Brain Regions of Female Sprague-Dawley Rats Endocrinology 136(5):2320-2324 (Exhibit G).
Singh, M., et al (1993) Ovariectomy Reduces ChAT Activity and NGF mRNA Levels in the Frontal Cortex and Hippocampus of the Female Sprague-Dawley Rat Society for Neuroscience Abstracts 19(2):1254, Abstract No. 514.11. (Exhibit H).
Shorabji, F., et al (1995) Identification of a Putative Estrogen Response Element in the Gene Encoding Brain-Derived Neurotrophic Factor Proc. Natl. Acad. Sci. USA 92:11110-11114. (Exhibit I).
Sohrabji, F., et al. (1994) Reciprocal Regulation of Estrogen and NGF Receptors by Their Ligands in PC12 Cells J. Neurobiology 25(8):974-988. (Exhibit J).
Sohrabji, F. et al. (1994) Estrogen Differentially Regulates Estrogen and Nerve Growth Factor Receptor mRNAs in Adult Sensory Neurons J. Neurosci. 14(2):459-471. (Exhibit K).
Toran-Allerand, C.D. (1996) The Estrogen/Neurotrophin Connection During Neural Development: Is Co-Localization of Estrogen Receptors with the Neurotrophins and Their Receptors Biologically Relevant? Dev. Neurosci. 18:36-48. (Exhibit L).
Toran-Allerand, C.D. (1996) Mechanisms of Estrogen Action During Neural Development: Mediation by Interactions with the Neurotrophins and Their Receptors? J. Steroid Biochem. Molec. Biol. 56:169-178. (Exhibit M).
Toran-Allerand, C.D., et al. (1992) Estrogen Receptors Colocalize with Low-Affinity Nerve Growth Factor Receptors in Cholinergic Neurons of the Basal Forebrain Proc. Natl. Acad. Sci. USA 89:4668-4672. (Exhibit N).
Toran-Allerand, C.D., et al. (1992) Cellular Variations in Estrogen Receptor mRNA Translation in the Developing Brain: Evidence from Combined [.sup.125 I] Estrogen Autoradiography and Non-Isotopic In Situ Hybridization Histochemistry Brain Research 576:25-41. (Exhibit O).
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Patel, Shirish V., `Pharmacotheraphy of Cognitive Impairment in Alzheimer's Disease: A Review`, J. Geriatr. Psychiatry. Neurol. vol. 8, pp. 81-95, Apr. 1995.
Gupta Anish
The Trustees of Columbia University in the City of New York
Tsang Cecilia J.
White John P.
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