Means for the diagnosis and therapy of CTCL

Details Means for the diagnosis and therapy of CTCL Means for the diagnosis and therapy of CTCL

2011-04-05

2011-04-05

Aeder, Sean E (Department: 1642)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reexamination Certificate

active

07919085

ABSTRACT:
The invention relates to a novel molecule, termed SC5 by the inventors, to a novel allelic form of p140, and to the biological applications of SC5 and p140 molecules, notably in the diagnosis and therapy of CTCL.

REFERENCES:
Christiansen et al (Mol Cancer Ther, 2004, 3:1493-1501).
Topp et al (Journal of Controlled Release, 1998, 53:15-23).
Jain (Scientific American Jul. 1994).
Dillman (Annals of Internal Medicine, vol. 111, pp. 592-603, 1989).
Weiner (Seminars Oncology, vol. 26, No. 4, 1999, pp. 41-50).
Gura (Science, 1997, 278:1041-1042.).
Musette, P. et al. “Polymorphic expression of CD158k/p140/KIR3DL2 in Sézary patients”,Blood, Feb. 1, 2003, p. 1203, vol. 101, No. 3.
Carrington, M. et al.The KIR Gene Cluster, Available from the NCBI Bookshelf (http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mono—003.TOC&depth=2), May 28, 2003, pp. pdf-1-pdf-48.
Ge, H. “UPA, a universal protein array system for quantitative detection of protein-protein, protein-DNA, protein-RNA and protein-ligand interactions”Nucleic Acids Res., 2000, vol. 28, No. 2, pp. i-vii.
Ruzicka, J. et al. “Bioligand Interaction Assay by Flow Injection Absorptiometry”Analytical Chemistry, Dec. 15, 1997, pp. 5024-5030, vol. 69, No. 24.
Walter, G. et al. “Protein arrays for gene expression and molecular interaction screening”Curr. Opin. Microbiol., 2000, pp. 298-302, vol. 3.
Nikolova, M. et al. “SC5, a novel functional cell structure expressed by Sezary syndrome cells”J. Immunol., 1995, vol. 55, No. 1862, Supp. 1 (abstract).
Pende, D. et al. “The Natural Killer Cell Receptor Specific for HLA-A Allotypes: A Novel Member of the p58/p70 Family of Inhibitory Receptors That Is Characterized by Three Immunoglobulin-like Domains and Is Expressed as a 140-kD Disulphide-linked Dimer”J. Exp. Med., Aug. 1996, pp. 505-518, vol. 184.
Linnemann, T. et al. “Identification of Epitopes for CTCL-Specific Cytotoxic T Lymphocytes”Advanced in Experimental Medicine and Biology, Gene Therapy of Cancer, 1998, pp. 231-235, vol. 451.
Derwent Publications Ltd., XP002167250 & RU 2104526, Feb. 10, 1998 (abstract).
Nikolova, M. et al. “Identification of cell surface molecules characterizing human cutaneous cell lymphomas”Leuk. Lymphoma, Apr. 2002, pp. 741-746, vol. 43, No. 4, abstract.
Musette, P. et al. “To the editor: Polymorphic expression of CD158k/p140/KIR3DL2 in Sezary patients”Blood, p. 1203, Feb. 1, 2003, vol. 101, No. 3.
Carrington, M. et al. “The KIR Gene Cluster” pp. pdf-1-48.
Alberts, B. et al., Molecular Biology of the Cell, 3rdedition, 1994, p. 465, Garland Publishing, Inc.
Lewin, B. “Regulation of transcription” inGenes VI, Chapter 29, 1997, pp. 847-848, Oxford University Press, Inc., New York.
Fu, L. et al. “Translational regulation of human p53 gene expression”EMBO Journal, 1996, pp. 4392-4401, vol. 15.
Mallampalli, R.K. et al. “Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP: cholinephosphate cytidylyltransferase activity in adult rat lung”.
Knox, S et al. “Treatment of Cutaneous T-Cell Lymphoma with Chimeric Anti-CD4 Monoclonal Antibody,”Blood, Feb. 1, 1996, pp. 893-899, vol. 87, No. 3.
Lundin, J. et al. “Phase II study of alemtuzumab (anti-CD52 monoclonal antibody, Campath-1H) in patients with advanced mycosis fungoides/Sézary syndrome,”Blood First Edition Paper, 2003, pp. 1-27.
Olsen, E. et al. “Pivotal Phase III Trial of Two Dose Levels of Denileukin Diftitox for the Treatment of Cutaneous T-Cell Lymphoma,”J. Clin. Oncol., Jan. 15, 2001, pp. 376-388, vol. 19, No. 2.

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