Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1984-05-14
1988-11-15
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 424431, 424446, 424447, A61K 3702, A61K 970
Patent
active
047849894
DESCRIPTION:
BRIEF SUMMARY
The present invention concerns means for removing microorganisms from tissue, such as mucous membranes, skin and wound tissue.
On skin and mucous membranes there is an indigenous flora of non-pathogenic as well as potentially pathogenic microorganisms. The presence of the indigenous flora serves certain useful functions and can prevent colorization of pathogenic microorganisms. Someone who in this way carries pathogenic microorganisms is a potential carrier of pathogens as the pathogenic microorganisms from such a person can be transferred to a tissue wound.
With the expression microorganisms is meant Gram-positive bacteria, such as different species of staphylococci, streptococci and pneumococci, Gram-positive rods, such as mycobacteria, e.g. Mycobacterium leprae, Gram-negative bacteria, such as different species of the family Enterobacteriaceae, e.g. Escherichia coli, Klebsiella, Proteus, Enterobacter or Vibrionacae, or Pseudomonas, as well as Gram-negative cocci, such as gonococci. This expression also includes anaerobic bacteria, such as Bacteroides, fusobacteria, anaerobic cocci, e.g. peptococci and peptostreptococci, as well as spirillae and spirochetes. Further included are fungi, such as Candida, e.g. Candida albicans, and dermatophytes, as well as pathogenic amoebae, such as Entamoeba histolytica, and Giardia lamblia and Leishmania.
The ways of removing microorganisms from tissue vary due to type of tissue and microorganism, respectively. For removing pathogenic microorganisms from mucous membranes and skin tissue a disinfectant or antibiotic is often used. A drawback with this is that the indigenous flora is removed as well, and thus the functions it serves. Further drawbacks are that disinfectants are cell toxic and that today many pathogenic strains have developed resistence against a large number of antibiotics. The removal of pathogenic microorganisms from wound tissue is carried out in several ways. One way is a direct attack on the microorganisms by treatment with disinfectants or antibiotics, but this is inefficient and results in the above mentioned drawbacks the indigenous flora. Another way is mechanical cleaning of wound tissue by means of moist saline dressings. The drawbacks with this are i.a. that the tissue healing is inhibited and that such dressings must be changed very often. The latter is an example of a more indirect way of removing pathogenic microorganisms from wound tissue. The secretions from the wound tissue are excellent substrate for microorganisms, and by reducing the amount thereof the growth of the microorganisms will also be decreased. Other methods wherein this indirect way is used are treatment of wounds by means of suitable polymers, e.g. in particle form, which polymers absorb the secretions from the wound tissue. Some of these secretion-absorbing polymers contain complexly bound iodine (so called iodophores), and with these a secretion-absorption and a disinfection are simultaneously achieved.
The present invention concerns means for removing microorganisms from tissue without influencing the indigenous flora in any greater extent.
A predominant cause of primary wound infections and postsurgical infections are certain Gram-positive cocci, such as Staphylococcus aureus and so called .beta.-hemolysing streptococci from group A, C and G. Pathogenic staphylococci exist everywhere in the environment, also that of a hospital where up to 80% of the personnel can be carriers of pathogens. Yellow staphylococci (S. aureus) colonize especially in certain parts of the skin, such as the axilla, the bottom of the pelvis and on the hand as well as in the nose. Even in dry eczema there is a frequent existence of white as well as yellow staphylococci. The common tonsillitis bacteria Strepococcus pyogenes (group A streptococcus) exists in a high frequency on nursing personnel as well as patients. Nosocomial infections are often transferred exogenic (from e.g. personnel to a patient) or endogenic (patients having these microorganisms on skin or mucous membranes infect their own w
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Hook Magnus
Wadstroom Torkel
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