Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1988-10-06
1991-04-02
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 9, 436501, 436503, 436543, 436548, 436 63, 436811, 435960, G01N 3353, G01N 33567, G01N 33577, A61K 4900
Patent
active
050046837
ABSTRACT:
The present invention is an improved means for detecting neuroanatomical pathways in animals comprising introducing an atoxic fragment C of tetanus toxin into the motor target of a neural circuit, and permitting the atoxic fragment to transport through the neural circuitry. The fragment C of tetanus toxin is then localized along the neuroanatomical pathway by reacting the fragment C with monospecifically reactive antibody produced by a hybridoma cell line selected from the group consisting of .alpha.TTC-17, .alpha.TTC-44, .alpha.TTC-49 and .alpha.TTC-114. The present invention also includes the individual hybridoma cell lines which produce the reactive antibody along with the antibody themselves.
REFERENCES:
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Erichsen Jonathan T.
Evinger Craig
Karten Harvey J.
Hoffer Florina B.
Kepplinger Esther L.
The Research Foundation of State University of New York
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