Means for caries prophylaxis

Drug – bio-affecting and body treating compositions – Dentifrices – Fluorine or fluorine compound containing

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424 54, A61K 718, A61K 722

Patent

active

040013936

ABSTRACT:
Disclosed are compositions containing 1,6-di-4'-fluorophenyldiguanidohexane and/or its non-toxic inorganic or organic salts as a means for caries prophylaxis.

REFERENCES:
patent: 2684924 (1954-07-01), Rose et al.
patent: 2863919 (1958-12-01), Birtwell et al.
patent: 2990425 (1961-06-01), Senior
patent: 3152181 (1964-10-01), Shapiro et al.
patent: 3887712 (1975-06-01), Lover et al.
Rose et al. (II) J. Chem. Soc. pp. 4422-4425 (1956) "Bis Biguanides Having Antibacterial Activity".
Gjermo et al. J. Periodont. Res. 8: Suppl. 12: 81-88 (1973) "Effect on Dental Plaque Formation and Some in Vitro Properties of 12 Bis-Biguanides".
Warner et al. J. Med. Chem. 16(6): 732-733 (1973) "1,6-bis(N.sup.5 -m-trifluoromethylphenyl-N'-biguanido)-hexane and Relates Analogs of Chlorhexidine as Inhibitors of Dental Plaque".
Chem. Abst. 71 No. 59413f (1969); 75 No. 47428j, No. 74792e (1971); 78 No. 33814g; No. 52942p No. 102001d (1973); 79 No. 87586y; 79 No. 111547j (1973); 80 No. 52342j, 55883x, 128097f (1974).

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