Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2011-08-23
2011-08-23
Gamett, Daniel C (Department: 1647)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C424S094640, C424S145100, C424S130100, C514S007700, C514S007900, C514S008100, C514S013500, C514S013700, C514S014600, C514S015300, C514S020100
Reexamination Certificate
active
08003096
ABSTRACT:
Described are methods of modulating stem/progenitor cell recruitment involving molecules that agonize the formation of plasmin stimulating the recruitment of stem/progenitor cells, including hematopoietic and endothelial precursor cells. Conversely, antagonists of plasmin can inhibit recruitment of the stem cells. In addition, the identification of the uPA receptor (uPAR) as a retention signal for stem cells in their niche suggests a novel method for increased engraftment and isolation of multipotent stem cells.
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Carmeliet Peter
Tjwa Marc
Gamett Daniel C
Life Sciences Research Partners VZW
TraskBritt
Vlaams Interuniversitair Instituut voor Biotechnologie VZW
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