Means and methods for purifying Clq, Clr and Cls

Details Means and methods for purifying Clq, Clr and Cls Means and methods for purifying Clq, Clr and Cls

1981-07-27

1983-02-15

Lieberman, Allan

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112B, 424 85, C07G 700

Patent

active

043740618

ABSTRACT:
A novel resin is provided for use in chromatography to enable purification of plasma proteins Clq, Clr and Cls from Cohn Fraction I and other materials. An improved method results in obtaining substantially all of these materials from Cohn Fraction I or other media. The components of complement thus obtained are highly purified and retain full biological activity.

REFERENCES:
patent: 3959079 (1976-05-01), Mareschi
patent: 3959080 (1976-05-01), Dieter
patent: 3995018 (1976-11-01), Sjoquist
patent: 4224439 (1980-09-01), Ayers
patent: 4239743 (1980-12-01), Sedlacek
Assimeh, S. N. et al, J. Immunology, vol. 113, pp. 225-234, 1974.
Bing, D. H., Methods Enzymol, vol. 34, 731-746, 1974.
Bing, D. H. et al, Protides Biol. Fluids Proc. Colloq., vol. 23, 551.557, 1976.

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