Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2007-07-03
2007-07-03
Li, Q. Janice (Department: 1633)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S325000, C435S320100, C424S093100, C424S093200, C424S093210
Reexamination Certificate
active
10783510
ABSTRACT:
The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for fibroblast-like or macrophage-like cells, preferably synoviocytes. In one aspect, the nucleic acid delivery vehicle is a virus capsid or a functional part, derivative and/or analogue thereof. Preferably, the virus capsid is an adenovirus capsid. Preferably, the adenovirus is a subgroup B adenovirus, such as adenovirus 16. Preferably, the tissue tropism is provided by at least a tissue tropism determining part of an adenovirus fiber protein or a functional derivative and/or analogue thereof. The invention further presents methods for the treatment of diseases, such as joint related diseases.
REFERENCES:
patent: 5585254 (1996-12-01), Maxwell et al.
patent: 5631236 (1997-05-01), Woo et al.
patent: 5770442 (1998-06-01), Wickham et al.
patent: 5861290 (1999-01-01), Goldsmith et al.
patent: 6329190 (2001-12-01), Wickham et al.
patent: 6455314 (2002-09-01), Wickham et al.
patent: 6869936 (2005-03-01), Vogels et al.
patent: 99201545.3 (1999-05-01), None
patent: 0 978 566 (2000-02-01), None
patent: WO 96/26281 (1996-08-01), None
patent: WO 97/00326 (1997-01-01), None
patent: WO 98/32842 (1998-07-01), None
patent: WO 98/50053 (1998-11-01), None
patent: WO 00/52186 (2000-09-01), None
D'andrea et al, Biochem J. 1998;329:681-7.
Basler et al., “Sequence of the immunoregulatory early region 3 and flanking sequences of adenovirus type 35,” Gene, 1996, pp. 249-254, vol. 170.
Flomenberg et al., “Molecular Epidemiology Adenovirus Type 35 Infections in Immunocompromised Hosts,” The Journal of Infectious Diseases, Jun. 1987, pp. 1127-1134, vol. 155, No. 6.
Flomenberg et al., “Sequence and genetic Organization of Adenovirus Type 35 Early Region 3,” Journal of Virology, Nov. 1988, pp. 4431-4437, vol. 62, No. 11.
Gahery-Segard et al., “Immune response to recombinant Capsid Proteins of Adenovirus in Humans: Antifiber and Anti-Penton Base Antibodies Have a Synergistic Effect on Neutralizing Activity,” Journal of Virology, Mar. 1998, pp. 2388-2397, vol. 72, No. 3.
Kang et al., “Molecular Cloning and Physical Mapping of the DNA of Human Adenovirus Type 35,” Acta Microbiologica Hungarica, 1999, pp. 67-75, vol. 36, No. 1.
Krasnykh et al., “Generation of Recombinant Adenovirus Vectors with modified Fibers for Altering Viral Tropism,” Journal of Virology, Oct. 1996, pp. 6839-3846, vol. 70, No. 10.
Notice of Opposition to a European Patent, Patent No. 1054064, by Cell Genesys Inc., dated Jul. 5, 2005.
Rosenfeld et al., Adenovirus-Mediated Transfer of a recombinant alpha-1-Antitrypsin Gene to the Lung Epithelium in Vivo, Science, Apr. 19, 1991, pp. 431-434, vol. 252.
Roy et al., “Circumvention of Immunity to the Adenovirus major Coat Protein Hexon,” Journal of Virology, Aug. 1998, pp. 6875-6879, vol. 72, No. 8.
Stevenson et al., “Human Adenovirus Serotypes 3 and 5 Bind to Two Different Cellular receptors via the Fiber Head Domain,” Journal of Virology, May 1995, pp. 2850-2857, vol. 69, No. 5.
Stratford-Perricaudet et al., “Evaluation of the Transfer and Expression in Mice of an Enzyme-Encoding Gene Using a Human Adenovirus Vector,” Human Gene Therapy, 1990, pp. 241-256, vol. 1.
#Boucher et al., J. Clin. Invest., Feb. 1999, pp. 441-445, vol. 103.
#Bowie et al., Science, Mar. 1990, pp. 1306-1310, vol. 247.
#Crystal et al., Transfer of Gene to Human: Early Lessons and Obstacles to Success, 1995, Science, vol. 270, pp. 404-410.
#Deonarain, Expert Opin. Ther. Pat., 1998, pp. 53-69, vol. 8.
#Eck et al., Gene-Based Therapy, 1996 Goodman & Gilman's, pp. 77-101.
#Gall et al., Journal of Virology, 1996, pp. 2116-2123, vol. 70.
#Guzman et al., PNAS, 1994, pp. 10732-10736, vol. 91.
#Kaye et al., A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding, Sep. 1990, Proc. Natl. Acad. Sci., pp. 6922-6926, vol. 87.
#Lazarovits et al., J. Immunol., 1993, pp. 6482-6489, vol. 151.
#Lusky et al., Journal of Virology, 1998, pp. 2022-2032, vol. 72.
#Makrides et al., Protein Exp. Pur., 1999, pp. 183-202, vol. 17.
#Mei et al., Virol., 1998, pp. 254-266, vol. 240.
#Miller et al., FASEB J., 1995, pp. 190-199, vol. 9.
#Robbins et al., Pharmacol. Ther., 1998, pp. 35-47, vol. 80.
#Rudinger et al., Characteristics of the amino acids as components of a peptide hormone sequence, 1976, Peptide Hormones, pp. 1-7.
#Russell et al., Nat. Genet., Apr. 1998, pp. 325-330, vol. 18.
#Shang et al., J. Immunol., 1998, pp. 467-474, vol. 160.
#Stevenson et al., J. Virol., 1997, pp. 4782-4790, vol. 6.
#Su, et al., A Genetically Modified Adenoviral Vector Exhibits Enhanced Gene Transfer of Human Smooth Muscle Cells, Journal of Vascular Research 2001, pp. 471-478, vol. 38.
#Verma et al., Nature, 1997, pp. 239-242, vol. 389.
#Wickham et al., Increased In Vitro and In Vivo Gene Transfer by Adenovirus Vectors Containing Chimeric Fiber Protein, Nov. 1997, Journal of Virology, pp. 8221-8229, vol. 71, No. 11.
#Zink et al., Gene Ther. Mol. Biol., Jan. 2001, pp. 1-24, vol. 6.
Hanyuda et al., Activated leucocytes express and secrete macrophage inflammatory protein-1alpha upon interation with synovial fibroblasts of rheumatoid arthritis via a beta2-integrin/ICAM-1 mechanism, Rheumatology, 2003, pp. 1390-1397, vol. 42.
Kitamura et al., Unique Localization of Protein Gene Product 9.5 in Type B Synoviocytes in the Joints of the Horse, The Journal of Histochemistry & Cytochemistry, 1999, pp. 343-351, vol. 47, No. 3.
Firestein, Gary S., Immunologic Mechanisms in the Pathogenesis of Rheumatoid Arthritis, Journal of Clinical Rheumatology, Jun. 2005, pp. S39-S44, vol. 11, No. 3.
Fowler et al., Synovial Metaplasia, A Specialized Form of Repair, Arch Pathol Lab Med, Jun. 2002, pp. 727-730, vol. 126.
Zheng et al., Interleukin-1 receptor antagonist intervenes in signaling between different types of synoviocytes in rats with adjuvant arthritis, Acta Pharmacologica Sinica, Jan. 2006, pp. 111-118, vol. 27, No. 1.
Barland et al., Electron Microscopy of the Human Synovial Membrane, The Journal of Cell Biology, 1962, pp. 207-220, vol. 14.
Bout Abraham
Havenga Menzo Jans Emco
Schouten Govert Johan
Vogels Ronald
Crucell Holland B.V.
Li Q. Janice
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