MDR reversal agents

Details MDR reversal agents MDR reversal agents

1995-05-25

1997-06-17

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546290, 546302, 556427, 549369, 549374, 560 9, 564340, 564 54, 558411, 558418, 558423, 558425, 568 38, 568 45, 568 49, 568 56, C07D21172, C07D30900

Patent

active

056398875

ABSTRACT:
Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.

REFERENCES:
patent: 2969362 (1961-01-01), Twelt et al.
patent: 4792559 (1988-12-01), Regnier et al.
Mukaiyama, T. et al., Chem. Lett., 11:1177-80 (1976).
Windholz, M., Editor, The Merck Index, Ninth Edition #3300, 3302, 4146, 5985, 7115, 7711, 8933, 9047 (1976).

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