Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-25
1996-10-01
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546165, 546166, A61K 3147, C07D21506
Patent
active
055611419
ABSTRACT:
Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.
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Mukaiyama, T. et al., Chem. Lett., 11:1177-80 (1976).
Windholz, M., Editor, The Merck Index, Ninth Edition #3300, 3302, 4146, 5985, 7115, 7711, 8933, 9047 (1976).
Berger Dan M.
Dutia Minu D.
Hallett William A.
Paul Rolf
Powell Dennis
American Cyanamid Company
Ivy C. Warren
M. Mach D. Margaret
Milowsky Arnold S.
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