Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-07-16
1995-02-07
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546144, C07D21704, C07D21720, C07D21712
Patent
active
053876857
ABSTRACT:
Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.
REFERENCES:
patent: 2969362 (1961-01-01), Wilmette
patent: 4792559 (1988-12-01), Regnier
The Merck Index, Martha Windholz, editor, Ninth edition, 1976.
Mukaiyama, T. et al., Chem. Lett., 11:1177-80 (1976).
Berger Dan M.
Dutia Minu D.
Hallett William A.
Paul Rolf
Powell Dennis
Ivy C. Warren
M. Mach D. Margaret
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