MDM2-specific antisense oligonucleotides

Details MDM2-specific antisense oligonucleotides MDM2-specific antisense oligonucleotides

1998-05-06

2000-01-11

Degen, Nancy

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 243, 536 2431, C07H 2104

Patent

active

06013786&

ABSTRACT:
The invention provides methods to activate tumor suppressors. The invention further provides antisense oligonucleotides complementary to a portion of the MDM2-encoding RNA and methods for using such antisense oligonucleotides as analytical and diagnostic tools, as potentiators of transgenic animal studies and for gene therapy approaches, and as potential therapeutic agents. The invention also provides methods to augment and synergistically activate a tumor suppressor in conjunction with the use of a DNA-damage inducing agent.

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