MDC proteins and DNAs encoding the same

Details MDC proteins and DNAs encoding the same MDC proteins and DNAs encoding the same

1995-06-07

1998-01-06

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352523, 4353201, 536 235, 536 2431, 536 2433, C12Q 168, C12N 1512, C12N 1511

Patent

active

057053413

ABSTRACT:
The present invention provide a gene present in a commonly deleted region of a chromosome in breast and ovarian cancers and encoding a novel protein, the protein ("MDC protein") encoded by the gene and a method for the diagnosis of cancer by using an antibody combinable to the protein.
A detailed genetic map of human chromosome 17 was constructed to analyze the chromosome in breast and ovarian cancer tissues, and a gene encoding a novel protein was cloned and its structure was determined. As a result of gene analysis using DNA probes derived from the gene, a gene mutation was confirmed in breast cancer tissues. Moreover, a transformant carrying a plasmid containing the gene was grown to obtain the MDC protein. Furthermore, a monoclonal antibody was prepared by using the protein as an antigen.

REFERENCES:
Davis, N., et. al (1991) Science 253, 1268-1271.
Hartl, M., et al. (1991) Oncogene 6, 1623-1631.
Blackburn, E. H., et. al. (1984) Cell 36, 447-457.

Affiliated with

Also associated with

Rating

MDC proteins and DNAs encoding the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with MDC proteins and DNAs encoding the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MDC proteins and DNAs encoding the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2328210