Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-05-13
1996-09-03
Patterson, Jr., Charles L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
536 235, C07K 1400
Patent
active
055525261
ABSTRACT:
The present invention provide a gene present in a commonly deleted region of a chromosome in breast and ovarian cancers and encoding a novel protein, the protein ("MDC protein") encoded by the gene, a method for the diagnosis of cancer by using an antibody combinable to the protein, and others.
A detailed genetic map of human chromosome 17 was constructed to analyze the chromosome in breast and ovarian cancer tissues, and a gene encoding a novel protein was cloned and its structure was determined. As a result of gene analysis using DNA probes derived from the gene, a gene mutation was confirmed in breast cancer tissues. Moreover, a transformant carrying a plasmid containing the gene was grown to obtain the MDC protein. Furthermore, a monoclonal antibody was prepared by using the protein as antigen.
REFERENCES:
Emi, M., et al. (1993) Nature Genetics 5, 151-157.
Katagiri, T. et al. (1995) Cytogenet. Cell Genet. 68, 39-44.
Takeya, H., et al. (1990) J. Biol. Chem. 265(27), 16068-16073.
Scarborough, R. M., et al. (1993) J. Biol. Chem. 268(2), 1058-1065.
Emi Mitsuru
Nakamura Yusuke
Cancer Institute
Eisai Co. Ltd.
Patterson Jr. Charles L.
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