MD-1 inhibitors as immune suppressants

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S387100, C530S387900, C424S172100, C424S173100

Reexamination Certificate

active

10221154

ABSTRACT:
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an agent that inhibits MD-1 with or without an OX-2 protein or a nucleic acid encoding an OX-2 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of MD-1 or an agent that activates or stimulates MD-1.

REFERENCES:
patent: 2006/0094006 (2006-05-01), Franchini et al.
patent: WO99/24565 (1999-05-01), None
Begum et al. (1999) Biochem. Biophys. Res. Comm. 256:325-329.
Chan et al., J. Exp. Med., 1998, 188:93-101.
Newell et al., Transplantation, 2006, 81: 1-6.
Huang Z, Pharmacol. Ther., 2000, 86: 201-215.
Gorczynski, R. et al., “Regulation of Gene Expression of Murine MD-1 Regulates Subsequent T Cell Activation and Cytokine Production”. J. of Immunology, vol. 165, No. 4, p. 1925-1932(2000).
Begum, N.A. et al. “Human MD-1 Homologue is a BCG-Regulated Gene Product in Monocytes: Its Identification by Differential Display”. Biochem. & Biophy. Research Communications, vol. 256, p. 325-329 (1999).
Miura, Y. et al. “RP105 is Associated with MD-1 and Transmits an Activation Signal in Human B Cells”. Blood, vol. 92, No. 8 p. 2815-2822 (1998).
Miyake, K. et al. “Mouse MD-1, a Molecule that is Physically Associated with RP105 and Positively Regulates Its Expression”. J. of Immunology, The Williams & Wilkins Co., vol. 161, p. 1348-1353, (1998).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

MD-1 inhibitors as immune suppressants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with MD-1 inhibitors as immune suppressants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MD-1 inhibitors as immune suppressants will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3871838

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.