MD-1 inhibitors as immune suppressants

Details MD-1 inhibitors as immune suppressants MD-1 inhibitors as immune suppressants

2007-11-06

2007-11-06

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C530S387100, C530S387900, C424S172100, C424S173100

Reexamination Certificate

active

10221154

ABSTRACT:
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an agent that inhibits MD-1 with or without an OX-2 protein or a nucleic acid encoding an OX-2 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of MD-1 or an agent that activates or stimulates MD-1.

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