MCH4 and MCH5, apoptotic proteases

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

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435183, 435212, 530324, C12N 950, C12N 948, A61K 3800

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active

058518150

ABSTRACT:
The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof are also provided.

REFERENCES:
patent: 5605826 (1997-02-01), Wright et al.
Boldin et al., "A Novel Protein That Interacts with the Death Domain of Fas/AP01 Contains a Sequence Motif Related to the Death Domain", J. Biol. Chem. 270(14):7795-7798 (1995).
Chinnaiyan et al., "FADD, a Novel Death Domain-Containing Protein, Interacts with the Death Domain of Fas and Initiates Apoptosis", Cell 81: 505-512 (1995).
Fernandes-Alnemri et al., Mch3, A Novel Human Apoptotic Cysteine Protease Highly Related to CPP32, Cancer Research 55 (24):6045-6052 (1995).
Hillier et al., "The WashU-Merck EST Project", EMBL/Genbank Databases, Accession No. T9612, Sequence Reference HS91272 (1995).
Hillier et al., "The WashU-Merck EST Project", EMBL/Genbank Databases, Accession No. N42544, Sequence Reference HS544281 (1996).
Hsu et al., "TRADD-TRAF2 and TRADD-FADD Interactions Define Two Distinct THF Receptor 1 Signal Transduction Pathways", Cell 84:299-308 (1996).
Kischkel et al. "Cytotoxicity-dependent APO-1 (Fas/CD95) -associated proteins form a death-inducing signaling complex (DISC) with the receptor", The EMBO Journal 14 (22):5579-5588 (1995).
Mann, M. and Wilm, M., "Electrospray mass spectrometry for protein characterization", TIBS Trends in Biochemical Sciences 20:219-224 (1995).
Wilm et al., "Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry", Nature 379:466-469 (1996).
Barinaga, Marcia, "Cell Suicide: By ICE, Not Fire," Science 26:754-756 (1994).
Black et al., "Activation of Interleukin-1.beta. by a Co-induced Protease," FEBS Lett., 247:386-390 (1989).
Cerretti et al., "Molecular Cloning of the Interleukin-.beta. Converting Enzyme," Science 256:97-100 (1992).
Enarl et al., "Involvement of an ICE-like protease in Fas-mediated apoptosis," Nature 375:78-81 (1995).
Fernandes-Alnemri et al., "CPP32, a Novel Human Apoptotic Protein with Homology to Caenorhabditis elegans Cell Death Protein Ced-3 and Mammalian Interleukin-1.beta.-converting Enzyme," J. Biol. Chem. 269:30761-30764 (1994).
Gagliardini et al., "Prevention of Vertebrate Neuronal Death by the crmA Gene," Science 263:826-828 (1994).
Howard et al., "IL-1-Converting Enzyme Requires Aspartic Acid Residues for Processing of the IL-1.beta. Precursor at Two Distinct Sites and Does Not Cleave 31-kDa IL-1.alpha.," J. Immunol. 147:2964-2969 (1991).
Korsmeyer, Stanley J., "Regulators of Cell death," TIG 11(3):101-105 (1995).
Kostura et al., "Identification of a Monocyte Specific Pre-interleukin 1.beta. Convertase Activity," Proc. Natl. Acad. Sci. USA 86:5227-5231 (1989).
Kumar et al., "Induction of Apoptosis by the Mouse Nedd2 Gene, Which Encodes a Protein similar to the Product of the Caenorhabditis elegans Cell Death Gene ced-3 and the Mammalian IL-1.beta.-converting Enzyme," Genes Dev. 8:1613-1626 (1994).
Los et al., "Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis," Nature 375:81-83 (1995).
Miura et al., "Induction of Apoptosis in Fibroblasts by IL-1.beta.-Converting Enzyme, a Mammalian Homolog of the C. elegans Cell Death Gene ced-3," Cell 75:653-660.
Nagata and Golstein, "The Fas Death Factor," Science 267:1449-1456 (1995).
Ray et al., "Viral Inhibition of Inflammation: Cowpox Virus Encodes an Inhibitor of the Interleukin-1.beta. Converting Enzyme," Cell 69:597-604 (1992).
Reed, John C., "Mini-Review: Cellular Mechanisms of Disease Series; Bcl-2 and the Regulation of Programmed Cell Death," J. Cell Biol. 124:1-6 (1994).
Sleath et al., "Substrate Specificity of the Protease That Processes Human Interleukin-1.beta.," J. Biol. Chem. 265:14526-14528 (1990).
Steller, Hermann, "Mechanisms and Genes of Cellular Suicide," Science 267:1445-1449 (1995).
Thompson, Craig B., "Apoptosis in the Pathogenesis and Treatment of Disease," Science 267:1456-1462 (1995).
Thornberry et al., "A Novel Heterodimeric Cysteine Protease is Required for Interleukin-1.beta. Process in Monocytes," Nature 356:768-774 (1992).
Wang et al., "Ich-1, an Ice/ced-3-Related Gene, Encodes Both Positive and Negative Regulators of Programmed Cell Death, " Cell 78:739-750 (1994).
Walker et al., "Crystal Structure of the Cysteine Protease Interleukin-1.beta.-Converting Enzyme: A (p20/p10).sub.2 Homodimer," Cell 78:343-352 (1994).
Williams, Gwyn T., and Smith, Christopher A., "Molecular Regulation of Apoptosis: Genetic Controls on Cell Death," Cell 74:777-779 (1993).
Wilson et al., "Structure and Mechanism of Interleukin-1.beta. Converting Enzyme," Nature 370:270-275 (1994).
Yuan et al., "The C. elegans Cell Death Gene ced-3 Encodes a Protein Similar to Mammalian Interleukin-1.beta.-Converting Enzyme," Cell 75:641-652 (1993).

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