MB-35 a peptide enhancing the production of growth hormone and p

Details MB-35 a peptide enhancing the production of growth hormone and p MB-35 a peptide enhancing the production of growth hormone and p

1989-09-19

1992-07-21

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 530301, 530837, C07K 710, C07K 748, C07K 1300, A61K 3743

Patent

active

051324016

ABSTRACT:
A peptide of the formula ##STR1## has been isolated from thymosin fraction 5 (TF-5) and synthetically produced. This peptide, which has 100% homology with a region of histone 2A is able to stimulate and enhance the production of growth hormone (GH) and prolactin (PRL) by anterior pituitary cells. The peptide can be used alone or in combination with another growth hormone stimulant, such as growth hormone releasing factor (GRF), or prolactin hormone stimulant, such as thyrotropin releasing hormone (TRH) to increase the production of GH and PRL beyond that achievable with GRF and TRH alone.

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