Maytansinoids, pharmaceutical compositions thereof and methods o

Details Maytansinoids, pharmaceutical compositions thereof and methods o Maytansinoids, pharmaceutical compositions thereof and methods o

1979-11-09

1981-04-07

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602393P, C07D49816, A61K 31535

Patent

active

042606080

ABSTRACT:
Novel maytansinoids of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group which may optionally be substituted or a group of the formula: --A.sup.1 --Y.sup.1 wherein A.sup.1 is an alkylene group or a bond, and Y.sup.1 is a cycloalkyl, phenyl, indolyl or imidazolyl group which may optionally be substituted,

REFERENCES:
patent: 3896111 (1975-07-01), Kupchan et al.
patent: 4137230 (1979-01-01), Hashimoto et al.
Hanka et al., "Microbial Agents and Chemotherapy", vol. 6, No. 5, Nov. 1974, pp. 651-652.
Kupchan et al., "J. Am. Chem. Soc.", vol. 97, No. 18, Sep. 1975, pp. 5294-5295.
Higashide et al., "Nature", vol. 270, pp. 721-722, Dec. 1977.
Wani et al., "J.C.S. Chem. Comm." 1973, p. 390.
Kupchan et al., "J. Med. Chem." (1978), vol. 21, No. 1, pp. 31-37.

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