Maytansinoids, pharmaceutical compositions thereof and method of

Details Maytansinoids, pharmaceutical compositions thereof and method of Maytansinoids, pharmaceutical compositions thereof and method of

1980-06-06

1981-12-29

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602393P, A61K 31535, C07D49816, C07D52100

Patent

active

043082696

ABSTRACT:
Novel maytansinoids of the formula: ##STR1## wherein X is H or Cl, and R is a hydrocarbon residue or an azaheterocyclic group, said R group having at least one of water-solubilizing substituents, have antimitotic, antitumor and antimicrobial activities.

REFERENCES:
patent: 3896111 (1975-07-01), Kupchan et al.
patent: 4137230 (1979-01-01), Hashimoto et al.
patent: 4162940 (1979-07-01), Higashide et al.
patent: 4225494 (1980-09-01), Higashide et al.
patent: 4248870 (1981-02-01), Miyashita et al.
Kupchan et al., "Journal of Medicinal Chemistry" (1978) vol. 21, No. 1, pp. 31-37.
Journal of Pure and Applied Chemistry, vol. 11, Nos. 1 and 2 (1965) pp. 60, 61, 66-68 and 186-188.

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