Maytansinoids, pharmaceutical compositions thereof and method of

Details Maytansinoids, pharmaceutical compositions thereof and method of Maytansinoids, pharmaceutical compositions thereof and method of

1980-05-28

1981-12-29

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602393P, A61K 31535, C07D48816, C07D52100

Patent

active

043082688

ABSTRACT:
Novel maytansinoids of the formula: ##STR1## wherein X is H or Cl, and Y is Cl, OH, SH, CN, NO.sub.2, --OR or --S(O).sub.n R wherein R is slkyl, aryl, aralkyl or azaheterocyclic group which may be substituted, and n is 0, 1 or 2, have antimitotic, antitumor and antimicrobial activities.

REFERENCES:
patent: 3896111 (1975-07-01), Kupchan et al.
patent: 4137230 (1979-01-01), Hashimoto et al.
patent: 4162940 (1979-07-01), Higashide et al.
patent: 4248870 (1981-02-01), Miyashita et al.
Kupchan et al., "J. Med. Chem." (1978), vol. 21, No. 1, pp. 31-37.

Affiliated with

Also associated with

Rating

Maytansinoids, pharmaceutical compositions thereof and method of does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Maytansinoids, pharmaceutical compositions thereof and method of, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Maytansinoids, pharmaceutical compositions thereof and method of will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1018444