Maytansinoids

Details Maytansinoids Maytansinoids

1980-09-17

1982-05-25

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435119, C07D49818

Patent

active

043315984

ABSTRACT:
Novel antibiotic C-15003 PHM, which is produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing antibiotic C-15003 PHM, and novel C-15003 PHM acylate, which is produced by subjecting C-15003 PHM thus obtained to acylation reaction with an acylating agent, have antiprotozoan and antitumor activities.

REFERENCES:
patent: 4137230 (1979-01-01), Hashimoto et al.
patent: 4151042 (1979-04-01), Higashide et al.
patent: 4162940 (1979-07-01), Higashide et al.
Wani, Journal of the Chemical Society, p. 390, 1973.
Kupchan, Journal of Organic Chemistry, vol. 42, p. 2349 (1977).
Higaside, Nature, vol. 270, p. 721 (1977).
Kupchan, J. Med. Chem., vol. 21, p.31 (1978).

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