Maytansinoids

Details Maytansinoids Maytansinoids

1980-05-14

1982-03-30

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42424854, 435119, C07D49818

Patent

active

043223486

ABSTRACT:
Novel Antibiotic C-15003PND, which has the formula: ##STR1## wherein R represents hydrogen, --CO--CH.sub.3, --CO--CH.sub.2 --CH.sub.3, ##STR2## is produced by cultivating a microorganism of the genus Nocardia. The Antibiotic C-15003PND wherein R is acetyl, propionyl, isobutyryl or isovaleryl is useful for an antifungal, antiprotozoal or antitumor agent and Antibiotic C-15003PND wherein R is hydrogen is useful for an intermediate thereof.

REFERENCES:
patent: 4162940 (1979-07-01), Higashide et al.
Kupchan et al., "Novel Maytansinoids. Naturally Occurring and Synthetic Antileukemic Esters of Maytansinol.sup.1-3 ", Journal of the Amer. Chem. Society, vol. 97, pp. 5294-5295 (1975).
Kupchan et al., "Novel Maytansinoids. Structural Interrelations and Requirements for Antileukemic Activity", Journal of the Amer. Chem. Society, vol. 96, pp. 3706-3708 (1974).
Higashide et al., "Ansamitocin, a group of novel maytansinoid antibiotics with anti properties from Nocardia", Nature, Inter. J. of Science, vol. 270 22/29, pp. 271-722 (Dec. 1977).
Kupchan et al., "The Maytansinoids. Isolation, Structural Elucidation, and Chemical Interrelation of Novel Ansa Macrolides", T. Journal of Organic Chemistry, vol. 42, No. 14, pp. 2349-2357 (Jul. 8, 1977).
Kupchan et al., Journal of Medicinal Chemistry, vol. 21, No. 1, pp. 31-37 (1978).

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