Maytansinoid compound

Details Maytansinoid compound Maytansinoid compound

1980-09-17

1982-12-07

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435119, 435872, 42424854, C07D49818

Patent

active

043626637

ABSTRACT:
Antibiotic C-15003 PND of the formula: ##STR1## wherein R is H or alkanoyl containing not more than 5 carbon atoms is produced by contacting a maytansinoid compound with a culture broth, inclusive of a processed matter derived therefrom, of a microorganism belonging to one of the genera Streptomyces and Chainia which is able to transform said maytansinoid compound into Antibiotic C-15003 PND.
Antibiotic C-15003 PND is useful as antitumor, antifungal or antiprotozoal agent.

REFERENCES:
patent: 4162940 (1979-07-01), Higashide et al.
patent: 4322348 (1982-03-01), Asai et al.

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