Maytansinoid analogs as antitumor agents

Details Maytansinoid analogs as antitumor agents Maytansinoid analogs as antitumor agents

2005-04-04

2010-11-23

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S229800, C540S456000

Reexamination Certificate

active

07838519

ABSTRACT:
Ansamycin analogs, including maytansinoid analogs, and their use in treating cell proliferative diseases and conditions, and in particular, for use as antitumor agents.

REFERENCES:
patent: 4364866 (1982-12-01), Asai et al.
patent: 58167592 (1983-10-01), None
patent: WO 2005/099754 (2005-10-01), None
Spiteller et al. (Journal of the American Chemical Society (2003), 125(47), 14236-14237).
Cassady et al., “Recent Developments in the Maytansidnoid Antitumor Agents”, Chem. Pharm. Bull, 52 (1): Jan. 1-26, 2004.
Kupchan, S.M. et al. “Maytansine, a Novel Antileukemic Ansa Macrolide fromMaytenus ovatus”, J. Am. Chem. Soc. vol. 94, p. 1354-1356, 1972.

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