Mature protein synthesis

Details Mature protein synthesis Mature protein synthesis

1980-04-11

1982-07-06

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435 70, 435172, 435317, 435253, C12P 2100

Patent

active

043383971

ABSTRACT:
A method is provided for synthesizing within a bacterial host, and secreting through the membrane of the host, a selected mature protein or polypeptide. The method involves:

REFERENCES:
patent: 4082613 (1978-04-01), Thirumalachar et al.
patent: 4237224 (1980-12-01), Cohen et al.
Villa-Komaroff et al., Proc. Natl. Acad. Sci. U.S.A., vol. 75, pp. 3727-3731, Aug. 1978.
Sutcliffe, Proc. Natl. Acad. Sci. U.S.A., vol. 75, pp. 3737-3741, Aug. 1978.
Roberts et al., Methods in Enzymology, vol. 68, pp. 473-483, (1979).
Morgan et al., Recombinant DNA and Genetic Experimentation, Pergamon Press, pp. 123-128, (1979).
U.S. Patent Application Ser. Nos. 913,533, filed 6/8/1978; 933,035, filed 8/11/1978.
Goeddel et al., "Direct Expression in Escherichia coli of a DNA Sequence Coding for Human Growth Hormone", Nature, 281, pp. 544-548, (1979).
Derynck et al., "Expression of Human Fibroblast Interferon Gene in Escherichia coli", Nature, 287, pp. 193-197, (Sep. 18, 1980).

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