Mature human fibroblast interferon

Details Mature human fibroblast interferon Mature human fibroblast interferon

1989-06-12

1995-10-24

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 854, 530351, C07K 1526, A61K 3766

Patent

active

054608112

ABSTRACT:
A cDNA library is constructed using mRNA from human fibroblasts induced with poly(I):poly(C). A bacterial clone containing fibroblast interferon cDNA sequences identified by hybridization to a cDNA probe synthesized using deoxyoligonucleotide primers which hybridize to fibroblast interferon mRNA specifically. Expression plasmids are constructed which permit the synthesis in E. coli of 8.times.10.sup.7 units of human fibroblast interferon per liter of culture. The bacterially produced fibroblast interferon is indistinguishable from authentic human fibroblast interferon by several critieria.

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