Matrix polymers for binding endotoxins

Details Matrix polymers for binding endotoxins Matrix polymers for binding endotoxins

1982-05-03

1985-01-01

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

525296, 525303, 525418, 536 11, 536 187, 536 22, 536 30, 536 43, 536 551, 536 553, 536 58, 536 63, 536 84, 536115, 536119, 536120, 536124, 424180, C07H 100

Patent

active

044916604

ABSTRACT:
An endotoxin binding material affixed to a support is disclosed. One embodiment is a matrix material capable of binding endotoxins and comprising a polar, water-insoluble, high molecular weight polymer support to which is attached groups which adsorb endotoxin molecules. The groups comprise bifunctional aliphatic molecules, one end of which is bound to the support, the other end of which is bound to an aryl molecule. The invention has utility in the removal of endotoxins from biological fluids and other solutions and for concentrating endotoxins so that they may be subsequently detected and quantified.

REFERENCES:
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patent: 4022962 (1977-05-01), Diamond
patent: 4025622 (1977-05-01), Ogura et al.
patent: 4185090 (1980-01-01), McIntire
Giul Badamova, et al., "Probl. Germalol Perelir Krovi", vol. 11, No. 7, pp. 19-23, 1966.
Saunders, et al., "Ion Exchange Process Ind.," Pap. Conf., 70, pp. 410-415, 1970.
Romanowska, "Analytical Biochemistry", vol. 33, pp. 383-389, 1970.
Rubio, "Jour. Chromatogr.", 57, pp. 148-150, 1971.
Bader, et al., "Z. Naturforsch", vol. 28, No. 7, pp. 422-430, 1973.
Nolan, et al., "Proceedings of the Society for Experimental Biology and Medicine", 149, pp. 766-770, 1975.
Romanowska, et al., 37 Febs Letters", vol. 66, No. 1, pp. 82-85, 1976.

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