Matrix mill for DNA extraction

Details Matrix mill for DNA extraction Matrix mill for DNA extraction

1997-11-04

2000-05-16

MacMillan, Keith D.

Chemistry: molecular biology and microbiology

Apparatus

4353061, 435803, 210695, 210222, 436174, 436177, 422186, 42218601, C12M 308, B01D 3506, G01N 100

Patent

active

060636165

ABSTRACT:
The device and methods herein disclosed were developed to allow a large number of small samples of organic tissue to be processed. The goal was to allow for the capture of these intracellular contents for study, use, and/or amplification. Though the device and specific protocols can be used to retrieve a variety of intracellular molecules one of the preferred embodiments particularly lends itself to the extraction of DNA. The electromagnetic device uses a set of terraced coils controlled in such a matter as to continually alternate polarity and thereby emulate the random motion of a manual mortal and pestle. This simulation of random motion is created through the arrangement of coils found in this invention. Methods were also developed to aid in the retrieval of DNA or other intracellular components using this device such that these components can be isolated and then used for study, amplification, or a variety of different purposes. Essentially the enclosed invention discloses a device and methodology which will allow for the rapid processing of many small tissue samples. This will assist in making such procedures as genotyping, genetic analysis, and gene mapping faster and more reliable on a large scale.

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