Matrix metalloproteinase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S416000, C544S296000, C544S310000, C548S453000, C548S472000, C560S180000, C562S430000, C562S450000

Reexamination Certificate

active

07601729

ABSTRACT:
Compounds of Formula (I):wherein:A represents bond, C1-6alkyl or CH═CH—C1-4alkyl;B represents bond, O, S, SO, SO2, CO, CR7R8, CO2R14, CONR14R15, N(COR14)(COR15), N(SO2R14)(COR15) or NR14R15;D represents bond, or C1-6alkyl;E represents substituted aryl or substituted or unsubstituted heteroaryl;Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring;X represents O, S, SO, SO2, CO, CNR5, CNOR5, CNNR5R6, NR11or CR7R8;Y represents CR5OR11, CR5SR11, NOR5, CR5NR6R11, SO, SO2, CO, CNR5, CNOR5or CS;R1and R1′each independently represents H, C1-6alkyl or C1-4alkylaryl;R2represents CO2R12, CH2OR12or CONR12R13, CONR12OR13, NR12COR13, SR12, PO(OH)2, PONHR12or SONHR12;R3represents H, C1-6alkyl or C1-4alkylaryl;R4represents optionally substituted aryl or heteroaryl;Z represents a bond, CH2, O, S, SO, SO2, NR5, OCR5R6, CR9R10O or Z, R4and Q together form an optionally substituted fused tricyclic group;R5and R6each independently represent H, C1-6alkyl or C1-4alkylaryl;R7and R8each independently represent H, halo, C1-6alkyl or C1-4alkylaryl;R9and R10each independently represents H, C1-6alkyl optionally substituted by halo, cyano, OR11or NR6R11, C1-4alkylaryl optionally substituted by halo, cyano, OR11 or NR6R11, OR11or, together with the N to which they are attached, R9and R10form a heterocyclic group:R11represents H, C1-6alkyl, C1-4alkylaryl or COR5;R12and R13each independently represent H, C1-3alkyl, C1-3alkylaryl or C1-3alkylheteroaryl or, together with the functionality to which they are attached, R12and R13form a heterocyclic group:R14and R15each independently represent H, C1-6alkyl, C1-4alkylaryl or C1-4alkylheteroaryl or together with the functionality to which they are attached R14and R15form a heterocyclic or fused heterocyclic group; and physiologically functional derivatives thereof, corresponding processes for preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metallproteinase enzymes (MMPs).

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