Matrix for sustained-release preparation

Details Matrix for sustained-release preparation Matrix for sustained-release preparation

1996-09-30

1997-09-09

Azpuru, Carlos A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424426, 424434, 424436, 424451, 424464, 5147723, 514785, A61K 950, A61K 948, A61F 202, A61F 902

Patent

active

056653948

ABSTRACT:
The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.

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