Matrix composition for human grafts/implants

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Muscle

Reexamination Certificate

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Details

C424S423000, C424S424000, C424S548000, C514S012200

Reexamination Certificate

active

07001430

ABSTRACT:
The present invention is directed to an intermediate composition for producing a muscle tissue matrix suitable for implantation in humans, comprising shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier, preferably a biocompatible acid solution, to form a muscle tissue slurry having a viscosity within the range of 1 centistoke to 20,000 centistokes measured at 25° C. In another aspect, the present invention is directed to a tissue implant comprising a human muscle tissue matrix.

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Djurhuus et al., “Methodological Aspects of measuring human skeletal muscle electrolyte content and ouabain binding capacity,” Anal Biochem 260:218-222, 1998.
Journal of Bone and Mineral Research, Apr. 2003, vol. 18, No. 4, p. 705, “In Vitro and In Vivo Synergistic Interactions Between the Runx2/Cbfa1 Transcription Factor and Bone Morphogenetic Protein-2 in Stimulating Osteoblast Differentiation”, Shuying Yang, Daoyan Wei, Dian Wang, Mattabhorn Phimphilai, Paul H. Krebsbach and Renny T. Franceschi.
Djurhuus M S et al.: “Methodological aspects of measuring human skeletal muscle electrolyte content and ouabain binding capacity.” Analytical Biochemistry. Jul. 1, 1998, vol. 260, No. 2., Jul. 1, 1998, pp. 218-222, XP002296843 ISSN: 0003-2697.

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