Matrix-bearing targets for maldi mass spectrometry and methods o

Details Matrix-bearing targets for maldi mass spectrometry and methods o Matrix-bearing targets for maldi mass spectrometry and methods o

1995-04-28

1998-06-23

Beck, Shrive

Coating processes

Spraying

427424, B05D 102

Patent

active

057702721

ABSTRACT:
The present invention provides new methods for producing substantially continuous, homogeneous layers of MALDI matrix materials deposited on MALDI targets and substantially free of voids and large crystals. The methods involve the deposition of MALDI matrix materials in a nebulized spray which is enveloped in a sheath of non-reactive gas which confines and entrains the spray and aids in the evaporation of the solvent such that substantial, if not complete, solvent evaporation occurs before the matrix material is deposited on the target surface. The invention further provides such matrix layers and pre-formed matrix-bearing targets for use in MALDI mass spectrometry.

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