Matrices with memories in automated drug discovery and units the

Details Matrices with memories in automated drug discovery and units the Matrices with memories in automated drug discovery and units the

1997-10-07

2000-10-24

Ludlow, Jan

Chemical apparatus and process disinfecting, deodorizing, preser

Control element responsive to a sensed operating condition

422101, 422104, 4352884, 4352885, 4352971, 4353031, 4353052, 935 88, B01L 300

Patent

active

061362743

ABSTRACT:
Automated drug discovery protocols, or partially automated protocols, in which matrices-with-memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microreactors and microvessels, which contain memories, an automated or semi-automated synthesizer, a microreactor washer/dryer, a manual or automated cleaver with a valved U-tube outlet for removing compounds from the matrix-with-memory microreactors, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodable during, after or before processing. Also provided are manual and automated methods for sorting matrices with memories.

REFERENCES:
patent: 4020830 (1977-05-01), Johnson et al.
patent: 4133642 (1979-01-01), Nosaka et al.
patent: 4176260 (1979-11-01), Ward et al.
patent: 4177253 (1979-12-01), Davies et al.
patent: 4297337 (1981-10-01), Mansfield
patent: 4452773 (1984-06-01), Molday
patent: 4680268 (1987-07-01), Clark, Jr.
patent: 4784162 (1988-11-01), Ricks et al.
patent: 4816513 (1989-03-01), Bidgham et al.
patent: 4821920 (1989-04-01), Lin et al.
patent: 4848559 (1989-07-01), Hoppmann et al.
patent: 4855583 (1989-08-01), Fraser et al.
patent: 4855909 (1989-08-01), Vincent et al.
patent: 4857893 (1989-08-01), Carroll
patent: 4915564 (1990-04-01), Eror et al.
patent: 4966154 (1990-10-01), Cooper et al.
patent: 4975647 (1990-12-01), Downer et al.
patent: 4995467 (1991-02-01), Niemann
patent: 5043222 (1991-08-01), Cherukuri
patent: 5046496 (1991-09-01), Betts et al.
patent: 5047371 (1991-09-01), Cherukuri
patent: 5053115 (1991-10-01), Wienberger et al.
patent: 5075077 (1991-12-01), Durley, III et al.
patent: 5093982 (1992-03-01), Gussman
patent: 5108819 (1992-04-01), Heller et al.
patent: 5128528 (1992-07-01), Heninger
patent: 5130362 (1992-07-01), Prasad et al.
patent: 5149629 (1992-09-01), Rishpon et al.
patent: 5152758 (1992-10-01), Kaetsu et al.
patent: 5156810 (1992-10-01), Ribi
patent: 5157262 (1992-10-01), Marsoner et al.
patent: 5184003 (1993-02-01), McMillan et al.
patent: 5186336 (1993-02-01), Pippin et al.
patent: 5211129 (1993-05-01), Taylor et al.
patent: 5262305 (1993-11-01), Heller et al.
patent: 5267151 (1993-11-01), Ham et al.
patent: 5268862 (1993-12-01), Rentzepis
patent: 5273715 (1993-12-01), Bridgham et al.
patent: 5273905 (1993-12-01), Muller et al.
patent: 5314058 (1994-05-01), Graham
patent: 5318676 (1994-06-01), Sailor et al.
patent: 5360728 (1994-11-01), Prasher
patent: 5380589 (1995-01-01), Goodman et al.
patent: 5405783 (1995-04-01), Pirrung et al.
patent: 5411647 (1995-05-01), Johnson et al.
patent: 5415999 (1995-05-01), Saul et al.
patent: 5421816 (1995-06-01), Lipkovker
patent: 5422266 (1995-06-01), Cormier et al.
patent: 5431691 (1995-07-01), Snell et al.
patent: 5435937 (1995-07-01), Bell et al.
patent: 5437284 (1995-08-01), Trimble
patent: 5443953 (1995-08-01), Hansen et al.
patent: 5447533 (1995-09-01), Vachon et al.
patent: 5482867 (1996-01-01), Barrett et al.
patent: 5498545 (1996-03-01), Vestal
patent: 5516491 (1996-05-01), Kath et al.
patent: 5521601 (1996-05-01), Kandlur et al.
patent: 5541061 (1996-07-01), Fodor et al.
patent: 5545531 (1996-08-01), Rava et al.
patent: 5634562 (1997-06-01), Isaacs
patent: 5751629 (1998-05-01), Nova et al.
patent: 5770157 (1998-06-01), Cargill et al.
patent: 5888830 (1999-03-01), Mohan et al.
Baldwin et al., Synthesis of a small molecule combinatorial library encoded with molecular tags, J. Am. Chem. Soc. 117:5588 (1995.
Combinatorial chemistry--playing electronic tag, Chem. & Indust. Magaz. News, Nov. 6, 1995.
Czarnik et al., No static at all, Chemistry in Britain, pp. 39-41 (Oct., 1996).
Ohlmeyer et al., "Complex synthetic chemical libraries indexed with molecular tags", Proc. Natl. Acad. Sci. 90:10922-10926, (1993).
Service, Memory enhanced microreactor chemistry, Science 270:577 (1995).
Xiao-yi et al., Combinatorial chemistry with laser optical encoding, Angew Chem. Int. Ed. Engl. 36(7): 780-782 (1997).

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