Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1996-09-30
1999-10-05
Zitomer, Stephanie W.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
422 55, 422 57, 422 58, 422 8205, 422102, 422104, 436164, 436165, 436518, 436524, 436528, 436531, 364496, 364497, 364499, 364550, 364570, G01N 3348, G01N 2101, G01N 33544, G06G 758
Patent
active
059619236
ABSTRACT:
Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
REFERENCES:
patent: 3017025 (1962-01-01), Stephen
patent: 3119099 (1964-01-01), Biernat
patent: 3781120 (1973-12-01), Engelhardt
patent: 4333072 (1982-06-01), Beigel
patent: 4382074 (1983-05-01), Hart
patent: 4507230 (1985-03-01), Tam et al.
patent: 4542102 (1985-09-01), Deltagupta et al.
patent: 4631211 (1986-12-01), Houghton
patent: 4908405 (1990-03-01), Bayer et al.
patent: 4927879 (1990-05-01), Pidgeon
patent: 5012236 (1991-04-01), Troyk et al.
patent: 5214409 (1993-05-01), Beigel
patent: 5235326 (1993-08-01), Beigel et al.
patent: 5242974 (1993-09-01), Holmes et al.
patent: 5250944 (1993-10-01), Urbas et al.
patent: 5252962 (1993-10-01), Urbas et al.
patent: 5257011 (1993-10-01), Beigel
patent: 5262772 (1993-11-01), Urbas et al.
patent: 5266926 (1993-11-01), Beigel
patent: 5324483 (1994-06-01), Cody et al.
patent: 5338665 (1994-08-01), Schatz et al.
patent: 5420579 (1995-05-01), Urbas et al.
patent: 5422636 (1995-06-01), Urbas et al.
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5432018 (1995-07-01), Dower et al.
patent: 5463564 (1995-10-01), Agrafiotis et al.
patent: 5489678 (1996-02-01), Fodor et al.
patent: 5527681 (1996-06-01), Holmes
patent: 5547839 (1996-08-01), Dower et al.
patent: 5549974 (1996-08-01), Holmes
patent: 5565324 (1996-10-01), Still et al.
patent: 5609826 (1997-03-01), Cargill et al.
patent: 5624711 (1997-04-01), Sundberg et al.
patent: 5639603 (1997-06-01), Dower et al.
patent: 5641634 (1997-06-01), Mandecki
patent: 5679773 (1997-10-01), Holmes
patent: 5770358 (1998-06-01), Dower et al.
Alper, J., "Drug discovery on the assembly line", Science. 264:1399-1401, 1994.
Basch et al., "Cell separation using positive immunoselective techniques," J. Immunol. Meths. 56:269-280 (1983).
Bayer et al., "New polymer supports for solid-liquid-phase synthesis," Chem. Pept. Proteins 3:3-8 (1986).
Berg et al., "Polystyrene-Grafted Polyethylene: Design of Film and Felt Matrices for Solid-Phase Peptide Synthesis," Innovation Perspect Solid Phase Synth. Collect. Pap., Int. Symp. 1st. Epton (ed.), (1990) pp. 453-459.
Berg et al., "Peptide synthesis on polystyrene-grafted polyethylene sheets," Pept., Proc. Eur. Pept. Symp., 20th, Jung et al. (Eds.), pp. 196-198.
Brenner et al., Encoded combinational chemistry, Proc. Natl. Acad. Sci. USA 89: 5381-5383 (1992).
Chen et al., "Analogous' organic synthesis of small-compound libraries: Validation of combinatorial chemistry in small-molecule synthesis," J. Am. Chem. Soc. 116:2661-2662 (1994).
Czarnik and Nova, "No static at all", Chemistry in Britian, 33(10):39-41 (1996).
Dave et al., "Sol-gel encapsulation methods for biosensors," Anal. Chem. 66(12):1120A-1127A (1994).
Devlin et al., "Random peptide libraries: A source of specific protein binding molecules," Science 249:404-406 (1990).
Dewitt et al., Diversomers.TM. technology. Solid phase synthesis, automation, and integration for the generation of chemical diversity. Drug Develop. Res. 33:116-124 (1994).
Dower & Fodor. "Chapter 26. The search for molecular diversity (II): recombinant and synthetic randomized peptide libraries," Ann. Rep. Med. Chem. 26:271-280 (1991).
Dunlap. Ed., "Immobilized Biochemicals and Affinity Chromatography," Symposium on Affinity Chromatography and Immobilized Biochemicals. Charleston, SC, 1973. Plenum Press, NY (1974).
Fenwick et al., "Application of the scintillation proximity assay technique to the determination of drugs," Analytical Proceedings Including Analytical Communications. Mar. 1994, vol. 31 (presented at the Euroanalysis VIII Conference held Sep. 5-11, 1993, University of Edinburgh).
Gallop. et al., "Applications of combinatorial technologies to drug discovery. 1.background and peptide combinatorial libraries," J. Med. Chem. 37(9):1233-1251 (1994).
Gordon et al., "Applications of combinatorial technologies to drug discovery. 2.Combinatorial organic synthesis, library screening strategies, and future directions," J. Med. Chem. 37(10):1385-1401 (1994).
Houghten, General method for the rapid solid-phase synthesis of large numbers of peptides. Specificity of antigen-antibody interaction at the level of individual amino acids, Proc. Natl. Acad. Sci. USA 82:5131 (1985).
Houghten et al., "The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides," BioTechniques 13(3):412-421 (1992).
Houghten et al., "Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery," Nature 354:84-85 (1991).
Immobilized Enzymes, Antigens, Antibodies and Peptides. Preparation and Characterization. Howard H. Weetall, Ed., Marcel Dekker, Inc., N.Y. (1975).
Jung et al., "Multiple peptide synthesis methods and their applications," Angew. Chem. Int. Ed. Engl. 31(4):367-488 (1992).
Kabat and Mayer, Experimental Immunochemistry. Chapter 40. Equilibrium Dialysis, Charles C. Thomas, Springfield, Illinois. (1961) pp. 715-718.
Kessler, "Peptoids -- A new approach to the developement of pharmaceuticals," Angew. Chem. Int. Ed. Engl. 32(4): 543-544 (1993).
Liskamp. Opportunities for new chemical libraries: Unnatural biopolymers and diversomers, Angew. Chem. Int. Ed. Engl. 33(6):633-636 (1994).
Maeji et al., Grafted supports used with the multipin method of peptides synthesis, Reactive Polymers 22:203-2121 (1994).
Martin et al., Measuring diversity: Experimental design of combinatorial libraries for drug discovery. J. Med. Chem. 38:1431 (1995).
Miles & Hales. "Labelled Antibodies and Immunological Assay Systems," Nature. 219:186-189 (1968).
Mjalli and Toyonaga, "Solid support combinatorial chemistry in lead discovery and SAR optimization," NetSci 1(1): (1995).
Nicolaou et al., "Radiofrequency combinatorial chemistry," Agnew. Chem. 34:2289-2291 (1995).
Nikolaiev et al., Peptide-encoding for structure determination of nonsequencable polymers within libraries synthesized and tested on solid-phase supports. Peptide Research (1992).
Rapp et al., "Polystyrene-polyoxyethylene graftcopolymers for high speed peptide synthesis," Pept. Proc. Eur. Pept. Symp. 20th Jung et al., eds., pp. 199-201 (1989).
Scott and Craig, "Random peptide libraries," Bio/Technology 5:40-48 (1994).
Scott et al., "Random peptide libraries," Current Biology 5:40-48 (1994).
Stewart and Young, Solid Phase Peptide Synthesis, 2d Ed., Pierce Chemical Co., pp. 53-73 (1984).
Wong, "Conjugation of proteins to solid matrices," Chemistry of Protein Conjugation and Cross Linking, 12:295-317 (1993).
David Gary S.
Nova Michael P.
Parandoosh Zahra
Potash Hanan
Satoda Yozo
IRORI
Zitomer Stephanie W.
LandOfFree
Matrices with memories and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Matrices with memories and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Matrices with memories and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1167913