Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2006-05-30
2006-05-30
Webman, Edward J. (Department: 1617)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
C424S499000, C424S489000, C424S486000, C424S487000, C424S488000, C514S951000, C514S952000
Reexamination Certificate
active
07052719
ABSTRACT:
A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the drug is released over longer periods of time as compared to release from the polymeric matrix not incorporating the hydrophobic compound into the polymeric material. In contrast to methods in which a surfactant or lipid is added as an excipient, the hydrophobic compound is actually integrated into the polymeric matrix, thereby modifying the diffusion of water into the microparticle and diffusion of solubilized drug out of the matrix. The integrated hydrophobic compound also prolongs degradation of hydrolytically unstable polymers forming the matrix, further delaying release of encapsulated drug.
REFERENCES:
patent: 3776001 (1973-12-01), Hanke
patent: 4818542 (1989-04-01), DeLuca et al.
patent: 5342628 (1994-08-01), Picha
patent: 5762961 (1998-06-01), Roser et al.
patent: 5855913 (1999-01-01), Hanes et al.
patent: 5942253 (1999-08-01), Gombotz et al.
patent: 6565885 (2003-05-01), Tarara et al.
patent: 2144407 (1994-03-01), None
patent: 43 37 492 (1995-05-01), None
patent: 231281 (1990-12-01), None
patent: 264500 (1996-06-01), None
patent: WO 96/03984 (1996-02-01), None
patent: WO 96/15815 (1996-05-01), None
patent: WO 98/04292 (1998-02-01), None
Beck, et al., “A New Long-Acting Injectable Microcapsule System For The Administration of Progesterone,”Fertility and Sterility31(5):545-551 (1979).
Benita, et al., “Characterization of Drug-Loaded Poly(d,l-lactide) Microsheres,”J. Pharmaceutical Sciences73(12):1721-1724 (1984).
Federal Register vol. 62, No. 85, pp. 24301-24309 (May 1997).
Mathiowitz, et al., “Morphology of Polyanhydride Microsphere Delivery Systems”J. Scanning Microscopy4(2):329-340(190).
Mathiowitz, et al., “Novel Microcapsules For Delivery Systems”Reactive Polymers6:275-283(1987).
Bernstein Howard
Chickering Donald
Khattak Sarwat
Straub Julie
Acusphere, Inc.
Pabst Patent Group LLP
Webman Edward J.
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