Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1996-03-15
1998-08-11
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
433215, 4332171, A61K 716
Patent
active
057925089
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to materials for treatment of periodontal disease, and more specifically to materials for treatment of periodontal disease suitable for use for the treatment of severe periodontal disease which require periodontal surgery for regeneration of periodontal tissues and restoration of occlusive function.
PRIOR ART
Periodontal disease is an inflammatory disease in which dental supporting apparatus (gingiva, periodontal membrane, alveolar bone) is destroyed by dental plaque (a lump of bacteria), and it, along with dental caries, are said to constitute the two major diseases in the field of dentistry.
In this disease, the connecting tissue (periodontal fibers) between the tooth and gingiva is destroyed, resulting in pocket formation. As the disease progresses, this pocket becomes deeper and the alveolar bone is destroyed and absorbed. If this condition is left untreated, the tooth may in some cases fall out spontaneously.
With recent advancement in the treatment/prophylaxis of dental caries and progress toward the aging society, periodontal disease has attracted increasing attention and its treatment has become an important subject.
Severe periodontal disease requires reconstruction of the periodontal tissue by a surgical procedure. Its purposes are not only to remove the periodontal pocket but also to recover occlusive function through regeneration of the periodontal tissue destroyed by periodontal disease. A representative surgical technique currently performed is gingival flap operation. However, concerning the postoperative mode of healing, true attachment accompanied by neogenesis of the cementum (new attachment) is limited only to the apical region and ideal attachment is not achieved in other regions (epithelial attachment). Under these circumstances, various techniques have recently been attempted to positively achieve new attachment. They include, for example, root decalcification with citric acid and the like, root treatment using an extracellular matrix, guided tissue regeneration technique (GTR technique), and grafting of a tooth with attached cultured periodontal membrane cells to its root. However, none of these methods are satisfactory as remedies.
Among these techniques, the GTR technique is a method in which invasion of the epithelium and gingival connective tissue, which is considered to disturb postoperative new attachment, is physically eliminated and cells derived from the periodontal membrane, which is thought to be responsible for formation of the cementum, are selectively utilized. This technique has begun to be applied in general clinical practice in the U.S.A. and Sweden. This technique may be summarized as follows.
The pocket formed by periodontal disease is surgically excised, the gingival flap is separated and the contaminated cementum corresponding to the pocket is completely scaled off. Then, a membrane is inserted between the tooth and the gingiva, and the gingiva placed on the membrane is sutured.
This technique is based on the conception that the intervention of the membrane accelerates (upward) growth of periodontal cells remaining in the apical region toward the crown region, thereby facilitating new attachment.
Although data from animal experiments and clinical tests have been published indicating usefulness of this technique, clinicians do not put full reliance on it. The reasons are: that a question arises as to the conception which is the basis of this technique, that handling of the membrane and intraoperative management are difficult, and that data denying the usefulness of the membrane have been published (though an improvement has been made from the early unabsorbable membranes to absorbable ones).
DISCLOSURE OF THE INVENTION
The present invention has been made under these circumstances and its objective is to provide materials for treatment of periodontal disease, and in particular, to provide, on an industrial basis and at inexpensive prices, high-performance materials for treatment of periodontal disease, whi
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Kitamura Hiroyuki
Nishigaki Mitsuru
Nishimura Kazuaki
Yamaoka Akira
Yoshikawa Etsuo
Kanebo Ltd.
Rose Shep K.
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