Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1997-03-25
1999-02-02
Lankford, Jr., Leon B.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
424 937, 623 11, 623 16, 128898, C12N 500
Patent
active
058664157
ABSTRACT:
The invention concerns methods for the production of in vitro constituted biological materials and their subsequent use as implants for healing cartilage and bone defects. A biological composite (28) comprising periosteum (22) and cartilage or bone forming cells (26) is described as well as an in vitro cultured periosteum.
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patent: 5655546 (1997-08-01), Halpern
patent: 5700289 (1997-12-01), Breitbart et al.
patent: 5713374 (1998-02-01), Pachene et al.
Brittberg, 1994, Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation, The new England Journal of Medicine, vol. 331 No. 14 pp. 889.
Skoog, 1976, The formation of articular cartilage from free perichondrial grafts, Plastic & reconstructive Surgery, vol. 57, No. 1 pp. 1.
Rubak, 1982, Chondrogenesis in repair of articular cartilage defects by free periosteal grafts in rabbits, Acta orthop. Scand, vol. 53 pp. 181.
Nakahara, 1990, Culture-expanded periosteal-derived cells exhibit osteochondrogenic potential in porous calcium phospate ceramics in Vivo, Clinical Orthopaedics and Related Research, vol. 276, pp. 291.
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