Materials comprising and methods of preparation and use for ribo

Details Materials comprising and methods of preparation and use for ribo Materials comprising and methods of preparation and use for ribo

1992-12-09

1995-05-16

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

43525233, 4353201, C07H 2102, C12N 1570, C12N 121

Patent

active

054162025

ABSTRACT:
The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins (RIPs) such as gelonin and analogs of the RIPs having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. The RIPs and RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents of the invention which include gene fusion products and immunoconjugates. Cytotoxic therapeutic agents or immunotoxins according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent, and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease.

REFERENCES:
patent: 4853871 (1989-08-01), Pantoliano et al.
patent: 4888415 (1989-12-01), Lambert et al.
patent: 5101025 (1992-03-01), Piazak, Jr. et al.

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