Materials and methods relating to the identification and sequenc

Details Materials and methods relating to the identification and sequenc Materials and methods relating to the identification and sequenc

1996-11-25

2000-04-04

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 235, 536 243, 536 2431, 536 231, 4353201, C07H 2102, C07H 2104, C12Q 168

Patent

active

060459972

ABSTRACT:
The identification and sequencing of the BRCA2 gene is disclosed as well as the amino acid sequence of the corresponding BRCA2 polypeptides. BRCA2 alleles including those with mutations in the BRCA2 gene which are associated with a predisposition to develop cancer, especially breast and ovarian cancer are also disclosed. The present invention further relates to polypeptides encoded by the above nucleic acid. The present invention further relates to uses of much BRCA2 nucleic acid and BRCA2 polypeptides, in particular in the diagnostic, prognostic or therapeutic treatment of cancer.

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