Materials and methods relating to protein aggregation in...

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C800S003000, C800S012000, C800S014000, C800S025000

Reexamination Certificate

active

07834237

ABSTRACT:
Disclosed is a method of inducing or modeling a disease associated with pathological tau protein aggregation. The method can be carried out in vitro and animal models, and may be used to screen for therapeutic, prognostic or diagnostic agents.

REFERENCES:
patent: 2928767 (1960-03-01), Gulesich et al.
patent: 5827644 (1998-10-01), Floyd et al.
patent: 5898094 (1999-04-01), Duff et al.
patent: 5912410 (1999-06-01), Cordell et al.
patent: 6953794 (2005-10-01), Wischik et al.
patent: 2003/0217370 (2003-11-01), Giasson et al.
patent: 2006/0014216 (2006-01-01), Wischik et al.
patent: 2 370 212 (2000-05-01), None
patent: 0 457 295 (1991-11-01), None
patent: 0 618 968 (1994-10-01), None
patent: 0 737 671 (1996-10-01), None
patent: 0 909 814 (1999-04-01), None
patent: 0 911 390 (1999-04-01), None
patent: 0 911 398 (1999-04-01), None
patent: 2001-352860 (2000-06-01), None
patent: WO 89 03993 (1989-05-01), None
patent: WO 93 01348 (1993-02-01), None
patent: WO 93 03369 (1993-02-01), None
patent: WO 93 11231 (1993-06-01), None
patent: WO 95 05466 (1995-02-01), None
patent: WO 95/05601 (1995-02-01), None
patent: WO 96 03177 (1996-02-01), None
patent: WO 96 04915 (1996-02-01), None
patent: WO 96 05837 (1996-02-01), None
patent: WO 96 30766 (1996-10-01), None
patent: WO 99 62548 (1999-12-01), None
patent: WO 01 53340 (2001-07-01), None
patent: WO 01 95709 (2001-12-01), None
patent: WO 02/055720 (2002-07-01), None
patent: WO 02/075318 (2002-09-01), None
patent: WO 03/007933 (2003-01-01), None
patent: WO 2005/030676 (2005-04-01), None
patent: WO 2006/032879 (2006-03-01), None
Nacharaju, Parimala, et al., Accelerated filament formation from tau protein with specific FTDP-17 missense mutations, FEBS Letters 447 (1999)195-199, Jacksonville, FL.
Spillantini, Maria Grazia, et al., “Mutation in the tau gene in familial multiple system tauopathy with presenile dementia,”Proc. Natl. Acad. Sci. USA, vol. 95, Jun. 1998, pp. 7737-7741.
Yoshida, Hirotaka, et al., “Functional effects oftaugene mutations Δand N296H,”J. of Neurochemistry, 2002, 80, 548-551, Cambridge, UK.
R. Lai, “The role of abnormal phosphorylation of tau protein in the development of neurofibrillary pathology in Alzheimer's disease”, Christ's College, 1994, pp. 1-243.
C. Wischik, “Molecular neuropathology of Alzheimer's disease”, 1989, pp. 44-70.
E. Montejo de Garcini, et al., “Self assembly of microtubule associated protein Tau into filaments resembling those found in Alzheimer disease”, Biochemical and Biophysical Research Communications, 1986, pp. 790-797.
E. Montejo de Garcini, et al., “In vitro conditions for the self-polymerization of the microtubule-associated protein”, J. Biochem., 1987, vol. 102, No. 6, pp. 1415-1421.
E. Montejo de Garcini, et al., “Tau factor polymers are similar to paired helical filaments of Alzheimer's disease”, Elsevier Science Publishers B.V., 1988, pp. 150-154.
H. Ksiezak-Reding and S.H. Yen, “Structural stability of paired helical filaments requires microtubule-binding domains of tau: A model for self-association”, Neuron, 1991, vol. 6, pp. 717-728.
U.S. Appl. No. 11/391,675, filed Mar. 29, 2006, C. M. Wischik, et al.
H. Wille, “Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro”, J. Cell Biol., 118, 1992, pp. 573-584.
H. Ksiezak-Reding.and J.S. Wall, “Mass and physical dimensions of two distinct populations of paired helical filaments”, Neurobiology of Aging, 1994, vol. 15, No. 1, pp. 11-18.
C.M. Wischik, et al., “Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease”, Proc. Natl. Acad. Sci. USA, 1988, vol. 85, pp. 4506-4510.
C.M. Wischik, et al., “Structural characterization of the core of the paired helical filament of Alzheimer disease”, Proc. Natl. Acad. Sci. USA, 1988, vol. 85, pp. 4884-4888.
C.M. Wischik, et al., “Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines”, Proc. Natl. Acad. Scie. USA, 1996, vol. 93, pp. 11213-11218.
H. Ksiezak-Reding, “Assembled tau filaments differ from native paired helical filaments as determined by scanning transmission electron microscopy”, STEM, 1998, pp. 86-98.
R. Mena, et al., “A progressive deposition of paired helical filaments (PHF) in the brain characterizes the evolution of dementia in Alzheimer's disease”, Journal of Neuropathology and Experimental Neurology, 1991, pp. 474-490.
R. Mena, et al., “Monitoring pathological assembly of tau and β-amyloid proteins in Alzheimer's diesease”, Acta Neuropathol, 1994, pp. 50-56.
R. Mena, et al., “Staging and pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease”, Acta Neuropathol, 1995, pp. 633-641.
C.M. Wischik, et al., “Quantitative analysis of tau protein in paired helical filament preparations” Implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer's disease, Neurobiology of Aging, 1995, vol. 16, No. 3, pp. 409-431.
C.M. Wischik, et al., “Author's response to commentaries”, Neurobiology of Aging, 1995, vol. 16, No. 3, pp. 423-431.
C.M. Wischik, et al., “Structure, biochemistry and molecular pathogenesis of paired helical filaments in Alzheimer's disease”, Pathbiology of Alzheimer's Disease, 1995, pp. 10-39.
V.M.-Y. Lee et al., “A68: A major subunit of paired helical filaments and derivatized forms of normal tau”, Science, 1991, vol. 251, pp. 675-678.
M. Goedert, et al., “Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms”, Neuron, Jan. 1992, vol. 8, pp. 159-168.
R. Jakes, et al. “Identification of 3- and 4-repeat tau isoforms within the PHF is Alzheimer's disease”, The EMBO Journal, 1991, vol. 10, No. 10, pp. 2725-2729.
M. Novak, et al., Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament:, The EMBO Journal, 1993, vol. 12, No. 1, pp. 365-370.
S.-H. Yens, et al., “Alzheimer's neurofibrillary tangles contain unique epitopes in common with the heat-stable microtubule-associated proteins tau and MAP2”, American Journal of Pathology, 1987, vol. 126, pp. 81-91.
J.-P. Brion, et al., “Characterization of a partial cDNA specific for the high molecular weight microtubule-associated protein MAP2 that encodes epitopes shared with pared helical filaments of Alzheimer's disease”, Dementia, 1990, vol. 1, pp. 304-315.
M.W. Klymkowsky, “Weaving a tangled web: the interconnected cytoskeleton”, Nature Cell Biology, 1999, vo. 1, No. 5, p. E121.
R. Brandt, “Cytoskeletal mechanisms of axon outgrowth and pathfinding”, Cell Tissue Res., 1998, vol. 292, 181-189.
D. van Rossum, et al., “Cytoskeletal dynamics in dendritic spines: direct modulation by glutamate receptors”, Trends Neurosci., 1992, vol. 22, pp. 290-295.
R. Sato-Harada, et al., “Microtubule-associated Proteins Regulate Microtubule Function as the Track for Intracellular Membrane Organelle Transports”, Cell Structure Function 21, 1996, pp. 283-295.
A. Grover, et al., “5′ splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of Exon 10*”, The Journal of Biological Chemistry, 1999, May 21 issue, vol. 274, No. 21, pp. 15134-15143.
M. Hutton, et al. “Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17”, Nature, Jun. 18, 1998, vol. 393, pp. 702-705.
T. Ishihara, et al., “Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoforms”, Neuron, Nov. 1999, vol. 24, pp. 751-762.
A. Harada, et al.,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Materials and methods relating to protein aggregation in... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Materials and methods relating to protein aggregation in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Materials and methods relating to protein aggregation in... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4239089

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.