Materials and methods relating to immune responses to fusion...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C435S455000, C536S023400

Reexamination Certificate

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07816334

ABSTRACT:
The invention provides nucleic acid construct and nucleic acid expression vectors directing the expression of a fusion protein consisting of a disease peptide antigen and a first domain of FrC of tetanus toxin. The invention provides nucleic acid (DNA) vaccines for use in inducing an immune response against a disease. There is also provided methods of producing nucleic acid constructs and vectors for use as nucleic acid (DNA) vaccines.

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patent: WO 99/15671 (1999-04-01), None
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Panina-Bordignon et al. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur. J. Immunol. 19:2237-2242, 1989.
Spellenberg, M.B., “DNA vaccines against lymphoma,” Journal of Immunology, 159:1885-1892, (1997).
Valmori, D., et al., “Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination,” Journal of Immunology, 149:717-721, (1992).
King, C.A., et al., “DNA vaccines with single-chain Fv fused to fragment C of tetanus toxi induce protective immunity against . . . ,” Nature Medicine, 4:1281-1286, (1998).
Herreros, J., et al., “C-terminal half of tetanus toxin fragment C is sufficient for neuronal binding and interaction with a . . . ,” Biochemical Journal, 347:199-204, (2000).
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