Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-05-12
2010-06-22
Ulm, John D (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S069700, C436S501000, C536S023400
Reexamination Certificate
active
07741064
ABSTRACT:
The invention provides materials and methods relating to G-protein coupled receptor (GPCR) oligomers. Complexes of two or more GPCRs associated with G-proteins are provided. Also provided are fusion proteins comprising a GPCR and a G-protein, nucleic acids, expression vectors and host cells. Methods of producing the complexes and fusion proteins of the invention are also provided.
REFERENCES:
patent: 5462856 (1995-10-01), Lerner et al.
patent: 6051386 (2000-04-01), Lerner et al.
patent: 6365356 (2002-04-01), Gershengorn
patent: 6468756 (2002-10-01), Bonini et al.
patent: 6555339 (2003-04-01), Liaw et al.
patent: 7105308 (2006-09-01), Chan-Hui et al.
patent: 7119190 (2006-10-01), Liaw et al.
patent: 2001/0053848 (2001-12-01), Patel et al.
patent: 2002/0137054 (2002-09-01), Aubart et al.
patent: WO 98/46995 (1998-10-01), None
Carrillo, et al. Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins. The Journal of Biological Chemistry, 2003, vol. 278, No. 43, pp. 42578-42587.
Carrillo, et al. Measurement of agonist-dependent and -independent signal initation of α1b—adrenoceptor mutants by direct analysis of guanine nucleotide exchange on the G protein Gα11. The Journal of Pharmacology and Experimental Therapeutics, 2002, vol. 302, No. 3, pp. 1080-1088.
Duthey, et al. A single subunit (GB2) is required for G-protein activation by the heterodimeric GABAβreceptor. The Journal of Biological Chemistry, 2002, vol. 277, No. 5, pp. 3236-3241.
George, et al. G-protein-coupled receptor oligomerization and its potential for drug discovery. , Nature Reviews, Drug Discover, 2002, vol. 1, No. 10, pp. 808-820.
Greasley et al. Mutational and computational analysis of the α1b—Adrenergic Receptor. The Journal of Biological Chemistry, 2001, vol. 276, No. 49, pp. 42486-46494.
Hebert et al. Structural and functional aspects of G protein-coupled receptor oligomerization. Biochemistry and Cell Biology, 1998, vol. 76, pp. 1-11.
Ji et al. Cis- and trans-activation of hormone receptors: the LH receptor. Molecular Endocrinology, 2002, 16(6): 1299-1308.
Lee et al. Ophan G. protein-coupled receptors in the CNS. Current Opinion in Pharmacology, 2001, vol. 1, pp. 31-39.
Lee et al. Two defective heterozygous luteinizing hormone receptors can rescue hormone action. The Journal of Biological Chemistry, 2002, vol. 277, No. 1, pp. 15795-15800.
Milligan, et al. Oligomerisation of G-protein-coupled receptors. Journal of Cell Science, 2001, vol. 114, No. Pt. 7, pp. 1265-1271.
Milligan, et al. Prinicples: Extending the utility of [35S]GTP γS binding assays. Trends in Pharmacological Sciences, Elsevier, 2003, vol. 24, No. 2, pp. 87-90.
Molinari et al. Promiscuous coupling at receptor-Gα fusion proteins. The Journal of Biological Chemistry, 2003, vol. 278, No. 18, pp. 15778-15788.
Osugai et al. Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation. Journal of Biological Chemistry, 1997, vol. 272, No. 40, pp. 25006-25012.
Seifert et al. GPCR- Gα fusion proteins: molecular analysis of receptor-G-protein coupling. Trends in Pharmacological Sciences, Elsevier Trends Journal, Cambridge, 1999, vol. 20, No. 9, pp. 383-389.
Vassilatais et al. The G protein-coupled receptor repertoires of human and mouse. Proceedings of the National Academy of Sciences, 2003, vol. 100, No. 8, pp. 4903-4908.
Wess et al. Molecular basis of receptor/G-protein-coupling selectivity. Pharmacology and Therapeutics, 1998, vol. 80, No. 3, pp. 231-264.
Behan Dominic
Milligan Graeme
Bozicevic Field & Francis LLP
Keddie James S.
The University Court of the University of Glasgow
Ulm John D
LandOfFree
Materials and methods relating to G-protein coupled receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Materials and methods relating to G-protein coupled receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Materials and methods relating to G-protein coupled receptor... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4229086