Materials and methods relating to fusion proteins for...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S278100, C435S069100

Reexamination Certificate

active

07410643

ABSTRACT:
A nucleic acid construct is provided for delivery into living cells in vivo for inducing an immune response in a patient to an antigen; the construct directing the expression of a fusion protein, said fusion protein comprising said antigen and an adjuvant sequence derived from a plant viral coat protein. Methods for making constructs and methods of using such constructs for the treatment of infectious disease, cancer and B cell malignancy, are provided.

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patent: 91/15587 (1991-10-01), None
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Dalsgaard et al, Plant-derived vaccine protects target animals against a viral disease, Nature Biotechnology, vol. 1, Mar. 1997, pp. 248-252.
Hammond et al. Expression of the potyvirus coat protein mediated by recombinant vaccinia virus and assembly of potyvirus-like particles in mammalian cells, Archives of Virology, 143, pp. 1433-1439, 1998.
Smolenska et al. Production of a functional single chain antibody attached to the surface of a plant virus, FEBS Letters, 441, pp. 379-382, 1998.
Marusic et al. Chimeric Plant Virus Particles as Immunogens for Inducing Murine and Human Immune Responses against Human Immunodeficiency Virus Type 1, Journal of Virology, p. 8434-8439, Sep. 2001.
Santa Cruz et al. Assembly and Movement of a Plant Virus Carrying a Green Fluorescent Protein Overcoat, Proc. Natl. Acad. Sci. USA 93, 6286-6290, 1996.

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