Materials and methods relating to binding assays

Details Materials and methods relating to binding assays Materials and methods relating to binding assays

1997-02-06

1998-11-03

Budens, Robert D.

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

435 4, 435 71, 435 792, 436501, 436518, G01N 3350, G01N 3353

Patent

active

058307621

ABSTRACT:
Methods of optimising binding assays are disclosed using binding agents having binding sites specific for an analyte by varying the density of binding sites on a solid phase, advantageously extending the working range of the assay and/or improving the precision of the assay within a given range. Processes for manufacturing an assay kit following the optimisation method and to methods of carrying out assays for analytes using these assay kits are also provided.

REFERENCES:
patent: 5424220 (1995-06-01), Goerlach-Graw et al.
Noe et al., Brit J. Haematology 80:285-292, 1992.
Lindsay et al., Clin. Biochem 28(4):395-400, 1995.
Franek et al., J. Agric. Food Chem. 42:1369-1374, 1994.
Keilacker et al., Eur. J. Clin. Chem. Clin. Biochem 29:555-563, 1991.

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