Materials and methods for treatment of cancer

Details Materials and methods for treatment of cancer Materials and methods for treatment of cancer

2005-03-22

2010-12-21

Angell, J. E (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

Reexamination Certificate

active

07855182

ABSTRACT:
Glypican 5 is shown for the first time to have a role in proliferation of cancer cells, including tumors which do not show chromosomal amplification at 13q31. The use of glypican 5 (GPC5) antagonists and binding agents for the treatment of cancer, particularly rhabdomyosarcoma and breast cancer, is disclosed.

REFERENCES:
patent: WO 03/006611 (2003-01-01), None
Fitzgibbon, et al., “Refinement and evaluation of candidate genes within the 13q amplicon in germinal centre lymphoma”, Bllod, vol. 100, No. 11, p. ABS. No. 4258, (2002).
Ota, et al., “Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma”, Cancer Research, vol. 64, No. 9, pp. 3087-3095, (2004).
Yu, et al., “GPC5 is a possible target for the 13q31-q31 amplification detected in lymphoma cell lines”, Journal of Human Genetics, vol. 48, pp. 331-335, (2003).
Dean et al., “Antisense oligonucleotide-based therapeutics for cancer”, Oncogene (2003) 22, p. 9087-9096.

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