Materials and methods for the photodirected synthesis of...

Details Materials and methods for the photodirected synthesis of... Materials and methods for the photodirected synthesis of...

2011-06-07

2011-06-07

Riley, Jezia (Department: 1637)

Combinatorial chemistry technology: method, library, apparatus

Method of creating a library

C506S013000, C506S016000, C506S018000, C506S029000, C506S032000, C506S033000, C536S025300, C435S006120

Reexamination Certificate

active

07956011

ABSTRACT:
Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing the protecting group of the linker molecules or oligonucleotides and (ii) a polymer substantially lacking electronegative heteroatoms that are capable of hydrogen bonding with photogenerated acid. Methods of synthesizing an oligomer arrays are also described that use a film that restricts diffusion of reactants and products on the substrate during synthesis of the array and which includes a precursor of a deprotecting reagent. The method involves removing one or more of the non-required products of the deprotection reaction from the reactive array elements at which they are produced during the reaction, in order to displace the deprotection reaction towards completion.

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