Materials and methods for the detection of mycobacterium tubercu

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 912, 435 915, 435 9152, 435810, 536 237, 536 2432, 536 2433, 935 8, 935 17, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104

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057861498

ABSTRACT:
The present invention is directed to oligonucleotides useful in detection, e.g., by ligase chain reaction (LCR) of target DNA from Mycobacterium tuberculosis. The present invention is also directed to methods of detecting target DNAs from Mycobacterium tuberculosis.

REFERENCES:
Uyemura, K., et al., "Microanatomic clonality of gamma delta T cell in human leishmaniasis Lesions", Accession No. s80771/Journal of Immunology, 148:1205-11 (1993).
Rogall, T., et la., "Towards a Phylogeny and Definition of Species at the Molecular Level within the Genus Mycobacterium", Intern'l Journ. of Ssystematic Bacteriology, 40:4:323-30 (1990).
Hermans, et al., Insertion Element IS987 from Mycobacterium bovis BCG is Located in a Hot-Spot Integration Region for Insertion Elements in Mycobacterium tuberculosis Complex Strains, Infection and Immunity, 59(8):2695-2705 (1991).
Sjobring, et al., "Polymerase Chain Reaction for Detection of Mycobacterium tuberculosis", Journal of Clinical Microbiology, 28(10):2200-2204 (1990).

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