Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1998-04-27
2000-06-06
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 6, 435 71, C12Q 100, C12Q 168, G01N 3353
Patent
active
060716916
ABSTRACT:
This invention generally relates to materials and methods for modulating the differentiation of cells. Specifically provided are methods to promote or inhibit cell differentiation and methods to identify compounds that promote cellular differentiation.
REFERENCES:
Al-Khodairy, et al., "Identification and Characterization of New Elements Involved in Checkpoint and Feedback Controls in Fission Yeast," Mol. Biol. Cell. 5:147-160 (1994).
Andersen, et al., "Stem cell and transcription factors in the development of the mammalian neural crest," FASEB, J. 8:707-713 (1994).
Ausebel, et al., (Eds) Protocols in Molecular Biology, John Wiley & Sons (1994), pp. 9.6.3 through 9.6.12.
Bader and Fischman, "Immunochemical Analysis of Myosin Heavy Chain during Avian Myogenesis In Vivo and In Vitro," J. Cell Biol., 95:763-770 (1982).
Barr, et al., "Rearrangement of the PAX3 paired box gene in the pediatric solid tumour alveolar rhadbomyosarcoma," Nat. Genet., 3:113:117 (1993).
Benezra, et al., "The Protein Id: A Negative Regulator of Helix-Loop-Helix DNA Binding Proteins," Cell, 61:49-59 (1990).
Bishop, J.M., "The Molecular Genetics of Cancer," Science 235:305-311 (1987).
Budowle and Baechtel, "Modifications to improve the effectiveness of restriction fragment length polymorphism typing," Appl. Theor. Electrophor 1:181-187 (1990).
Carr, et al., "Control of cell cycle arrest by the Mec1.sup.sc /Rad.sup.sp DNA structure checkpoint pathway," Curr.Opin.Genet.Dev. 7:93-98 (1997).
Carr, et al., "Checkpoints Take the Next Step," Science, 217:314-315 (1996).
Cher, et al., "Genetic Alterations in Untreated Metastases and Androgen-independent Prostate Cancer Detected by Comparative Genomic Hybridization and Allelotyping," Cancer Res., 56:3091-3102 (1996).
Cimprich, et al., "cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein," Proc.Nat'l.Acad.Sci.(USA) 93:2850-2855 (1996).
Delihas, et al., "Natural antisense RNA/target RNA interactions: Possible models for antisense oligonucleotide drug design," Nature Biotechnology 15:751-753 (1997).
Dias, et al., "Myogenic Regulatory Protein (MyoD1) Expression in Childhood Solid Tumors: Diagnostic Utility in Rhabdomyosarcoma," Am.J.Pathol., 137:1283-1291 (1990).
Donehower, et al., "Mice deficient for p53 and developmentally normal but susceptible to spontaneous tumors," Nature, 356:216-221 (1992).
Fakharzadeh, et al., "Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line," EMBO J., 10:1565-1569 (1991).
Favaloro, et al., "Transcription Maps of Polyoma virus-Specific RNA: Analysis by Two-Dimensional Nuclease A1 Gel Mapping," Methods Enzymol, 65:718-749 (1980).
Fiddler, et al., "Amplification of MDM2 Inhibits MyoD-Mediated Myogenesis," Mol. Cell Biol. 16:5048-5057 (1996).
Fiszman and Fuchs, "Temperature-sensitive expression of differentiation in transformed myoblasts," Nature, 254:429-431 (1975).
Flaggs, et al., "Atm-dependent interactions of a mammalian Chk1 homolog with meiotic chromosomes," Curr. Biol. 7(12):977-986 (1997).
Fournier, et al., "A general high-efficiency procedure for production of microcell hybrids," Proc.Nat'l.Acad. Sci.(USA) 78:6349-6353 (1981).
Friedman, et al., "Progress Toward Human Gene Therapy," Science, 244:1275-1281 (1989).
Fukasawa, et al., "Abnormal Centrosome Amplification in the Absence of p53," Science 271:1744-1747 (1996).
Hardy, et al., "Fibroblast Growth Factor Inhibits MRF4 Activity Independently of the Phosphorylation Status of a Conserved Threonine Residue within the DNA-Binding Domain," Mol.Cell Biol., 13:5943-5956 (1993).
Hawley and Friend, "Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53," Genes Dev., 10:2383-2388 (1996).
Heselmeyer, et al., "Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix," Proc.Nat'l.Acad.Sci.(USA) 93:479-484 (1996).
Hiti, et al., "Expression of the MyoD1 Muscle Determination Gene Defines Differentiation Capability but Not Tumorigenicity of Human Rhabdomyosarcomas," Mol.Cell Biol., 9:4722-4730 (1989).
Hoekstra, et al., "Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family," Curr.Opin.Genet.Dev., 7:170-175 (1997).
Holtzer, et al., "Effect on oncogenic virus on muscle differentiation," Proc.Nat'l.Acad.Sci.(USA) 72:4051-4055 (1975).
Keegan, et al., "The Atr and Atm protein kinases associate with different sites along meoitically pairing chromosomes," Genes Dev., 10:2423-2437 (1996).
Lasser, et al., "Transformation by Activated ras or fos Prevents Myogenesis by Inhibiting Expressing of MyoD1," Cell, 58:659-667 (1989).
Li, et al., "FGF Inactivates Myogenic Helix-Loop-Helix Proteins through Phosphorylation of a Conserved Protein Kinase C Site in Their DNA-Binding Domains," Cell, 71:1181-1194 (1992).
Loh, et al., "Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma," Proc.Nat'l.Acad.Sci.(USA) 89:1755-1759 (1992).
Lugo, et al., "Isolation of Microcell Hybrid Clones Containing Retroviral Vector Insertions into Specific Human Chromosomes," Mol.Cell.Biol. 7:2814-2829 (1987).
Miller, et al., "Human gene therapy comes of age," Nature 357:455-460 (1992).
Mitchell, et al., "Molecular definition in a somatic cell hybrid of a specific 2:13 translocation breakpoint in childhood rhabdomyosarcoma," Oncogene, 6:89-92 (1991).
Morrison, et al., "Regulatory Mechanisms in Stem Cell Biology," Cell, 88:287-298 (1997).
Newsham, et al., "Microdissection of Chromosome Band 11p15.5: Characterization of Probes Mapping Distal to the HBBC Locus," Genes Chromosom. Cancer, 3:108-116 (1991).
Oliner, et al., "Amplification of a gene encoding a p53-associated protein in human sarcomas," Nature, 358:80 (1992).
Peterson, et al., "Negative Control of the Helix-Loop-Helix Family of Myogenic Regulators in the NFB Mutant," Cell, 62:493-502 (1990).
Porcher, et al., "The T Cell Leukemia Oncoprotein SCL/ta1-1 Is Essential for Development of All Hematopoietic Lineages," Cell, 86:47-57 (1996).
Rao, et al., "Ectopic Expression of Cyclin D1 Prevents Activation of Gene Transcription by Myogenic Helix-Loop-Helix Regulators," Mol.Cell Biol. 14:5259-5267 (1994).
Ried, et al., "Mapping of Multiple DNA Gains and Losses in Primary Small Cell Lung Carcinomas by Comparative Genomic Hybridization," Cancer Res., 54:1801-1806 (1994).
Rotman and Shiloh, "The ATM Gene and Protein: Possible Roles in Genome Surveillance, Checkpoint Controls and Cellular Defense against Oxidative Stress," Cancer Surv. 29:285-304 (1997).
Savitsky, et al., "A Single Ataxia Telangiectasia Gene with a Product Similar to P1-3 Kinase," Science, 268:1749-1753 (1995).
Scrable, et al., "Rhabdomyosarcoma-associated locus and MYOD1 are syntenic but separate loci on the short arm of human chromosome 11," Proc.Nat'l.Acad.Sci.(USA) 87:2182-2186 (1990).
Skapek, et al., "Inhibition of Myogenic Differentiation in Proliferating Myoblasts by Cyclin D1-Dependent Kinase," Science, 267:1022-1024 (1995).
Speicher, et al., "Comparative Genomic Hybridization Detects Novel Deletions and Amplifications in Head and Neck Squamous Cell Carcinomas," Cancer Res., 55:1010-1013 (1995).
Tapscott, et al., "Deficiency in Rhabdomyosarcomas of a Factor Required for MyoD Activity and Myogenesis," Science 259:1450-1453 (1993).
Taub, et al., "Transcriptional control of liver regeneration," FASEB J., 10:413-427 (1996).
Trask and Pinkel, Flow Cytometry, Methods in Cell Biology, vol. 33: New York Academic Press (1990).
Verma, "Treatment of disease by introducing healthy genes into the body is becoming feasible. But the therapy will not reach its full potential until the genes can be coaxes to work throughtout life," Scientific American 68-84 (1990).
Weber-Hall, et al., "Gains, Losses, and Amplification of Genomic Material in Rhabdomyosarcoma Analyzed by Comparative Genomic Hybridization," Cancer Res., 56:3220-3224 (1996).
Weintraub, et al., "Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast
Hoekstra Merl F.
Thayer Mathew J.
Oregon Health & Science University
Schwartzman Robert A.
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